CAS 182760-06-1: Ravuconazole

Description: Ravuconazole is an antifungal agent belonging to the class of triazoles, specifically designed to inhibit the enzyme lanosterol 14α-demethylase, which is crucial for ergosterol synthesis in fungal cell membranes. This mechanism of action makes it effective against a broad spectrum of fungal pathogens, including those responsible for systemic infections. Ravuconazole is characterized by its high oral bioavailability and favorable pharmacokinetic properties, which allow for effective treatment with less frequent dosing compared to some other antifungals. It exhibits a good safety profile, with adverse effects generally being mild and manageable. The compound is also notable for its potential use in treating various fungal infections, including those caused by species resistant to other antifungal agents. Its chemical structure includes a triazole ring, contributing to its activity and stability. Ravuconazole's development reflects ongoing efforts to enhance antifungal therapies, particularly in the context of increasing resistance among fungal pathogens.

Formula: C₂₂H₁₇F₂N₅OS

InChI: InChI=1S/C22H17F2N5OS/c1-14(21-28-20(10-31-21)16-4-2-15(9-25)3-5-16)22(30,11-29-13-26-12-27-29)18-7-6-17(23)8-19(18)24/h2-8,10,12-14,30H,11H2,1H3/t14-,22+/m0/s1

InChI key: InChIKey=OPAHEYNNJWPQPX-RCDICMHDSA-N

SMILES: N#CC=1C=CC(=CC1)C=2N=C(SC2)C(C)C(O)(C3=CC=C(F)C=C3F)CN4N=CN=C4

Synonyms:

• 4-[2-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile
• 4-{2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-1,3-thiazol-4-yl}benzonitrile
• Benzonitrile, 4-(2-((1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-4-thiazolyl)-
• Benzonitrile, 4-[2-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]-, [R-(R*,R*)]-
• Bms 207147
• Er 30346
• Ravuconazole
• Ravuconazole [INN]
• p-(2-((alphaR,betaR)-2,4-Difluoro-beta-hydroxy-alpha-methyl-beta-(1H-1,2,4-triazol-1-ylmethyl)phenethyl)-4-thiazolyl)benzonitrile

Benzonitrile, 4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]-

CAS: 182760-06-1

• Formula: C₂₂H₁₇F₂N₅OS
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 437.4651

Ravuconazole

CAS: 182760-06-1

• Formula: C₂₂H₁₇F₂N₅OS
• Molecular weight: 437.47

Ravuconazole-d4

CAS: 1329499-27-5 182760-06-1

• Formula: C₂₂H₁₃D₄F₂N₅OS
• Molecular weight: 441.49

Ravuconazole

CAS: 182760-06-1

Ravuconazole (ER-30346) is a potent triazole antifungal that potently inhibits a wide range of fungi.

• Formula: C₂₂H₁₇F₂N₅OS
• Purity: 99.84%
• Color and Shape: Solid
• Molecular weight: 437.47

Ravuconazole

CAS: 182760-06-1

Applications Ergosterol biosynthesis inhibitor. Antifungal. References Fung-Tomc., J.C., et al.: Antimicrob. Agents Chemother., 42, 313 …

• Formula: C₂₂H₁₇F₂N₅OS
• Color and Shape: Neat
• Molecular weight: 437.47

[R-(R*,R*)]-4-{2-[2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)-propyl]-4-thiazolyl}-benzonitrile

CAS: 182760-06-1

[R-(R*,R*)]-4-{2-[2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)-propyl]-4-thiazolyl}benzonitrile is an experimental drug that has been shown to have antimicrobial activity. It inhibits …

• Formula: C₂₂H₁₇F₂N₅OS
• Purity: Min. 95%
• Molecular weight: 437.47 g/mol