CAS 182760-06-1

Ravuconazole

Description:

Ravuconazole is an antifungal agent belonging to the class of triazoles, specifically designed to inhibit the enzyme lanosterol 14α-demethylase, which is crucial for ergosterol synthesis in fungal cell membranes. This mechanism of action makes it effective against a broad spectrum of fungal pathogens, including those responsible for systemic infections. Ravuconazole is characterized by its high oral bioavailability and favorable pharmacokinetic properties, which allow for effective treatment with less frequent dosing compared to some other antifungals. It exhibits a good safety profile, with adverse effects generally being mild and manageable. The compound is also notable for its potential use in treating various fungal infections, including those caused by species resistant to other antifungal agents. Its chemical structure includes a triazole ring, contributing to its activity and stability. Ravuconazole's development reflects ongoing efforts to enhance antifungal therapies, particularly in the context of increasing resistance among fungal pathogens.

Formula: C₂₂H₁₇F₂N₅OS

InChI: InChI=1S/C22H17F2N5OS/c1-14(21-28-20(10-31-21)16-4-2-15(9-25)3-5-16)22(30,11-29-13-26-12-27-29)18-7-6-17(23)8-19(18)24/h2-8,10,12-14,30H,11H2,1H3/t14-,22+/m0/s1

InChI key: InChIKey=OPAHEYNNJWPQPX-RCDICMHDSA-N

SMILES: [C@@]([C@@H](C)C1=NC(=CS1)C2=CC=C(C#N)C=C2)(CN3C=NC=N3)(O)C4=C(F)C=C(F)C=C4

Synonyms:

• 4-[2-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile
• 4-{2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-1,3-thiazol-4-yl}benzonitrile
• Benzonitrile, 4-(2-((1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-4-thiazolyl)-
• Benzonitrile, 4-[2-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]-, [R-(R*,R*)]-
• Bms 207147
• Er 30346
• Ravuconazole
• Ravuconazole [INN]
• p-(2-((alphaR,betaR)-2,4-Difluoro-beta-hydroxy-alpha-methyl-beta-(1H-1,2,4-triazol-1-ylmethyl)phenethyl)-4-thiazolyl)benzonitrile

Benzonitrile, 4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]-

CAS: 182760-06-1

Formula: C₂₂H₁₇F₂N₅OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 437.4651

Ref: IN-DA00244E

Ravuconazole

CAS: 182760-06-1

Formula: C₂₂H₁₇F₂N₅OS

Molecular weight: 437.47

Ref: 4Z-R-150001

4-(2-((2R,3R)-3-(2,4-Difluorophenyl)-3-Hydroxy-4-(1H-1,2,4-Triazol-1-Yl)Butan-2-Yl)Thiazol-4-Yl)Benzonitrile

CAS: 182760-06-1

4-(2-((2R,3R)-3-(2,4-Difluorophenyl)-3-Hydroxy-4-(1H-1,2,4-Triazol-1-Yl)Butan-2-Yl)Thiazol-4-Yl)Benzonitrile

Purity: 98%

Molecular weight: 437.47g/mol

Ref: 54-PC108774

Ravuconazole

CAS: 182760-06-1

Ravuconazole

Purity: ≥98%

Molecular weight: 437.47g/mol

Ref: 54-BUP10575

Ravuconazole-d4

CAS: 1329499-27-5, 182760-06-1

Formula: C₂₂H₁₃D₄F₂N₅OS

Molecular weight: 441.49

Ref: 4Z-R-150002

Ravuconazole

CAS: 182760-06-1

Formula: C₂₂H₁₇F₂N₅OS

Purity: >98.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 437.47

Ref: 3B-R0323

Ravuconazole

CAS: 182760-06-1

Ravuconazole (ER-30346) is a potent triazole antifungal that potently inhibits a wide range of fungi.

Formula: C₂₂H₁₇F₂N₅OS

Purity: 99.84%

Color and Shape: Solid

Molecular weight: 437.47

Ref: TM-T7152

RAVUCONAZOLE

CAS: 182760-06-1

Purity: 98%

Molecular weight: 437.4700012

Ref: 10-F857155

Ravuconazole

Controlled Product

CAS: 182760-06-1

Applications Ergosterol biosynthesis inhibitor. Antifungal.
References Fung-Tomc., J.C., et al.: Antimicrob. Agents Chemother., 42, 313 (1988), Tsuruoka, A., et al.: Chem. Pharm. Bull., 46, 623 (1998), Gupta, A.K., et al.: J. Eur. Acad. Dermatol. Venereol., 19, 437 (2005),

Formula: C₂₂H₁₇F₂N₅OS

Color and Shape: Neat

Molecular weight: 437.47

Ref: TR-R128000

Ravuconazole

CAS: 182760-06-1

Formula: C₂₂H₁₇F₂N₅OS

Molecular weight: 437.47

Ref: ST-EA-CP-R44003