CAS 182815-44-7

Colesevelam hydrochloride

Description:

Colesevelam hydrochloride is a bile acid sequestrant primarily used to lower cholesterol levels in patients with hyperlipidemia and to improve glycemic control in type 2 diabetes. It is a polymeric compound that binds bile acids in the intestine, preventing their reabsorption and promoting their excretion. This mechanism leads to a reduction in circulating cholesterol levels as the liver compensates for the loss of bile acids by converting cholesterol into bile acids. Colesevelam hydrochloride is characterized by its high molecular weight and low solubility in water, which contributes to its effectiveness in the gastrointestinal tract. The substance is typically administered in tablet form or as a powder for suspension, and it is generally well-tolerated, with gastrointestinal side effects being the most common. Additionally, it has a favorable safety profile, making it a suitable option for patients who may not tolerate other lipid-lowering therapies. Overall, colesevelam hydrochloride represents an important therapeutic option in the management of cholesterol and blood glucose levels.

Formula: (C₁₃H₂₇N)n·(C₁₂H₂₇ClN₂)n·(C₃H₇N)n·(C₃H₅ClO)n·xHCl

InChI: InChI=1/C13H29N.C12H29N2.C3H5ClO.C3H9N/c1-3-5-6-7-8-9-10-11-13-14-12-4-2;1-5-10-13-11-8-6-7-9-12-14(2,3)4;4-1-3-2-5-3;1-2-3-4/h14H,3-13H2,1-2H3;13H,5-12H2,1-4H3;3H,1-2H2;2-4H2,1H3/q;+1;;

InChI key: InChIKey=VTAKZNRDSPNOAU-UHFFFAOYSA-M

SMILES: C(CCCCNCC=C)C[N+](C)(C)C.[Cl-].C(CCCNCC=C)CCCCCC.C(CN)=C.C(Cl)C1CO1.Cl

Synonyms:

• 1-Decanamine, N-2-propenyl-, polymer with (chloromethyl)oxirane, 2-propen-1-amine and N,N,N-trimethyl-6-(2-propenylamino)-1-hexanaminium chloride, hydrochloride
• 1-Hexanaminium, N,N,N-trimethyl-6-(2-propen-1-ylamino)-, chloride (1:1), polymer with 2-(chloromethyl)oxirane, 2-propen-1-amine and N-2-propen-1-yl-1-decanamine, hydrochloride
• 1-Hexanaminium, N,N,N-trimethyl-6-(2-propen-1-ylamino)-, chloride, polymer with 2-(chloromethyl)oxirane, 2-propen-1-amine and N-2-propen-1-yl-1-decanamine, hydrochloride (1:?)
• 1-Hexanaminium, N,N,N-trimethyl-6-(2-propenylamino)-, chloride, polymer with (chloromethyl)oxirane, 2-propen-1-amine and N-2-propenyl-1-decanamine, hydrochloride
• 2-(Chloromethyl)Oxirane
• 2-Propen-1-amine, polymer with (chloromethyl)oxirane, N-2-propenyl-1-decanamine and N,N,N-trimethyl-6-(2-propenylamino)-1-hexanaminium chloride, hydrochloride
• 6-(Allylamino)Hexyl-Trimethyl-Ammonium
• Chloride
• CholestaGel
• Gt 31-104
• Gt 31-104Hb
• Hydrochloride
• N-allyldecan-1-amine
• N-propyldecan-1-amine
• Oxirane, (chloromethyl)-, polymer with 2-propen-1-amine, N-2-propenyl-1-decanamine and N,N,N-trimethyl-6-(2-propenylamino)-1-hexanaminium chloride, hydrochloride
• Prop-2-En-1-Amine
• Propan-1-Amine
• Trimethyl-[6-(Propylamino)Hexyl]Ammonium
• Welchol
• Colesevelam
• colesevelam hcl API
• Colesevelam USP
• Colesevelam Hydrochloride Q: What is the CAS Number of
• Colesevelam Hydrochloride
• Colesevelam HCL
• Colesevelam Hydrochloride Q: What is the storage condition of
• Colesevelam USP/EP/BP
• Colesevelam HydrochlorideQ: What is
• COLESEVALAM
• Colesevelam and Colesevelam Hydrochloride
• Colesevelam Hydrochloride Q: What are the applications of

Colesevelam Hydrochloride (Technical Grade)

Controlled Product

CAS: 182815-44-7

Applications Colesevelam Hydrochloride is used to reduce elevated low-density lipoprotein (LDL) cholesterol in patients with primary hyperlipidemia as well as to improve glycemic control in patients with type 2 diabetes. References Krishnaiah, Y., et al.: Drug Dev Ind Pharm, 40, 1173-1179 (2014)

Formula: (C₁₂H₂₇ClN₂•C₁₃H₂₇N•C₃H₇N•C₃H₅ClO)•(HCl)

Color and Shape: Neat

Molecular weight: x(234.81+197.36+57.09+92.52)+x(36.46)

Ref: TR-C640095

Colesevelam Hydrochloride

CAS: 182815-44-7

Colesevelam HCl is a bile acid sequestrant that reduces cholesterol by inhibiting bile reabsorption.

Formula: C₃₁H₆₇Cl₃N₄O

Purity: 98%

Color and Shape: Solid

Molecular weight: 618.25

Ref: TM-T35371