CAS 182912-74-9

(PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21)

Description:

(PRO18,ASP21)-Amyloid beta-protein (17-21) is a peptide fragment derived from the amyloid precursor protein, specifically representing a portion of the amyloid beta peptide associated with Alzheimer's disease. This peptide consists of a sequence of amino acids that includes proline at position 18 and aspartic acid at position 21, which are critical for its structural and functional properties. Characteristically, this peptide is known for its propensity to aggregate, forming oligomers and fibrils that are implicated in neurodegenerative processes. The aggregation of amyloid beta peptides is a hallmark of Alzheimer's pathology, contributing to plaque formation in the brain. Additionally, this peptide can influence cellular processes, including synaptic function and neuroinflammation. Its study is crucial for understanding the molecular mechanisms underlying Alzheimer's disease and for developing potential therapeutic strategies. The CAS number 182912-74-9 uniquely identifies this specific peptide, facilitating research and regulatory processes in biochemistry and pharmacology.

Formula: C₃₃H₄₃N₅O₈

Synonyms:

• [Pro18, Asp21]Amyloid-Beta Protein (17-21), Human, Mouse, Rat
• [Pro18, Asp21]-Amyloid B Protein Fragment 17-21 Trifluoroacetate Salt
• [Pro18, Asp21] Beta-Amyloid (17-21)
• Lpffd
• Beta-Sheet Breaker Peptide Ia-Beta5P
• Beta-Sheet Breaker Peptide Ia-Beta5
• Leu-Pro-Phe-Phe-Asp

β-Sheet Breaker Peptide iAß5 (Bulk)

CAS: 182912-74-9

β-Sheet Breaker Peptide iAß5 (Bulk) is a peptide that inhibits the formation of β-sheets in proteins. It has been shown to be an excellent inhibitor of protein interactions, with good selectivity for its target. This peptide also has high purity and can be used as a research tool for studying the function of ion channels and antibodies.

Formula: C₃₃H₄₃N₅O₈

Purity: Min. 95%

Molecular weight: 637.74 g/mol

Ref: 3D-PAB-3615-PI

β-Sheet Breaker Peptide iAß5

CAS: 182912-74-9

Beta-Sheet Breaker Peptide iAß5 is a peptide that interacts with amyloid beta proteins to disrupt the formation of beta sheets. It has been shown to inhibit the aggregation of amyloid beta proteins into oligomers and fibrils, and disrupts the self-assembly of amyloid beta protein into various conformations. Beta-Sheet Breaker Peptide iAß5 is a ligand for both receptor and activator binding sites on amyloid beta proteins, inhibiting the interaction of these sites. This inhibits the activation of downstream signalling pathways associated with Alzheimer's disease.

Formula: C₃₃H₄₃N₅O₈

Purity: Min. 95%

Molecular weight: 637.72 g/mol

Ref: 3D-PAB-4358-V

(Pro18,Asp21)-Amyloid b-Protein (17-21) trifluoroacetate salt

CAS: 182912-74-9

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Formula: C₃₃H₄₃N₅O₈

Purity: Min. 95%

Molecular weight: 637.72 g/mol

Ref: 3D-FP109385