CAS 1831862-88-4

Cholan-24-oic acid, 6-ethyl-7-hydroxy-, (5β,6α,7α)-

Description:

Cholan-24-oic acid, 6-ethyl-7-hydroxy-, (5β,6α,7α)-, is a steroidal compound characterized by its complex structure, which includes a cholane backbone typical of bile acids. This compound features a carboxylic acid functional group at the C24 position, an ethyl group at the C6 position, and a hydroxyl group at the C7 position, contributing to its unique chemical properties. The stereochemistry indicated by the (5β,6α,7α) configuration suggests specific spatial arrangements of the atoms, which can significantly influence its biological activity and interactions. Such compounds are often studied for their potential roles in biological systems, including their involvement in lipid metabolism and signaling pathways. The presence of hydroxyl and carboxylic acid groups enhances its solubility in polar solvents, which is important for its biological functions. Overall, cholan-24-oic acid derivatives are of interest in medicinal chemistry and biochemistry due to their structural diversity and potential therapeutic applications.

Formula: C₂₆H₄₄O₃

Synonyms:

• Cholan-24-oic acid, 6-ethyl-7-hydroxy-, (5β,6α,7α)-

FXR agonist 12

CAS: 1831862-88-4

FXR agonist12 (Compound C7) is an orally active FXR agonist. It downregulates bile acid synthesis-related genes and upregulates bile acid transport-related genes in HepG2 cells. FXR agonist12 alleviates ANIT-induced cholestasis and reduces liver damage and fibrosis in a mouse model of NASH.

Formula: C₂₆H₄₄O₃

Color and Shape: Solid

Molecular weight: 404.626

Ref: TM-T205709