CAS 183198-49-4

Iso Desloratadine

Description:

Iso Desloratadine, with the CAS number 183198-49-4, is a derivative of desloratadine, which is an antihistamine commonly used to treat allergic symptoms such as hay fever and hives. Iso Desloratadine is characterized by its selective antagonistic action on peripheral H1 histamine receptors, which helps alleviate allergy-related symptoms without causing significant sedation, a common side effect of many first-generation antihistamines. This compound is typically administered orally and exhibits a favorable pharmacokinetic profile, including rapid absorption and a relatively long half-life, allowing for once-daily dosing. Its chemical structure includes a piperidine ring and a carboxylic acid moiety, contributing to its biological activity. Iso Desloratadine is generally well-tolerated, with a low incidence of adverse effects, making it a preferred choice in the management of allergic conditions. As with any medication, it is essential to consider potential interactions with other drugs and individual patient factors when prescribing or using this substance.

Formula: C₁₉H₁₉ClN₂

Synonyms:

• 8-Chloro-6,11-dihydro-11-(1,2,3,6-tetrahydro-4-pyridinyl-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

8-Chloro-6,11-dihydro-11-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

CAS: 183198-49-4

Formula: C₁₉H₁₉ClN₂

Color and Shape: Solid

Molecular weight: 310.8206

Ref: IN-DA0027DR

Desloratadine EP Impurity B DiHCl (Iso Desloratadine DiHCl)

CAS: 183198-49-4

Formula: C₁₉H₁₉ClN₂·2HCl

Color and Shape: Red Solid

Molecular weight: 310.83 2*36.46

Ref: 4Z-L-1029

Iso Desloratadine

CAS: 183198-49-4

Impurity Desloratadine EP Impurity B
Stability Hygroscopic, Light Sensitive
Applications Iso Desloratadine (Desloratadine EP Impurity B) is an impurity of Desloratadine (D290250), which is a nonsedating-type histamine H1-receptor antagonist. Desloratadine is an active metabolite of Loratadine (L469575). Also inhibits generation and release of inflammatory mediators from basophils and mast cells. An impurity arising in the synthesis of Rupatadine (R701650).
References Kreutner, W., et al.: Arzneimittel-Forsch., 50, 345 (2000); Salmun, L.M., et al.: Clin. Ther., 22, 613 (2000); Agrawal, D.K., et al.: Expert Opin. Invest. Drugs, 10, 547 (2001);

Formula: C₁₉H₁₉ClN₂

Color and Shape: Off-White

Molecular weight: 310.82

Ref: TR-I814995

Desloratadine EP Impurity B

CAS: 183198-49-4

Formula: C₁₉H₁₉ClN₂

Molecular weight: 310.82

Ref: ST-EA-CP-D15002