CAS 183204-72-0
:Tipiracil hydrochloride
Description:
Tipiracil hydrochloride is a pharmaceutical compound primarily used as a co-administered agent with the chemotherapeutic drug trifluridine in the treatment of certain types of cancer, particularly metastatic colorectal cancer. It functions as a thymidine phosphorylase inhibitor, which enhances the efficacy of trifluridine by preventing its degradation and increasing its bioavailability. The compound is typically presented as a white to off-white crystalline powder, soluble in water, and exhibits stability under standard storage conditions. Its mechanism of action involves the inhibition of the enzyme that breaks down nucleoside analogs, thereby allowing for prolonged therapeutic effects. Tipiracil hydrochloride is administered orally and is often part of a combination therapy regimen. As with many pharmaceuticals, it may have side effects, including but not limited to gastrointestinal disturbances and hematological changes, necessitating careful monitoring during treatment. Overall, Tipiracil hydrochloride plays a crucial role in enhancing the effectiveness of cancer therapies, contributing to improved patient outcomes.
Formula:C9H11ClN4O2·ClH
InChI:InChI=1S/C9H11ClN4O2.ClH/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11;/h11H,1-4H2,(H2,12,13,15,16);1H
InChI key:InChIKey=KGHYQYACJRXCAT-UHFFFAOYSA-N
SMILES:C(C1=C(Cl)C(=O)NC(=O)N1)N2C(=N)CCC2.Cl
Synonyms:- 2,4(1H,3H)-Pyrimidinedione, 5-chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-, hydrochloride (1:1)
- 2,4(1H,3H)-Pyrimidinedione, 5-chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-, monohydrochloride
- 5-Chloro-6-(2-iminopyrrolidin-1-ylmethyl)uracil hydrochloride
- 5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione monohydrochloride
- 5-Chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4(1H,3H)-dione hydrochloride
- TPI hydrochloride
- Tas 1-462
- Tipiracil
- Tipiracil HCl
- Tipiracil hydrochloride
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Found 9 products.
Tipiracil HCl
CAS:Formula:C9H11ClN4O2·HClColor and Shape:White To Off-White SolidMolecular weight:242.67 36.46Tipiracil-13C-15N2 HCl
CAS:Formula:C813CH11ClN215N2O2·HClColor and Shape:White To Off-White SolidMolecular weight:245.64 36.46Tipiracil hydrochloride
CAS:<p>Tipiracil hydrochloride (MA-1 hydrochloride) is a thymidine phosphorylase inhibitor (TPI).</p>Formula:C9H12Cl2N4O2Purity:98.13% - ≥95%Color and Shape:SolidMolecular weight:279.125-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione monohydrochloride
CAS:<p>Trifluridine is a pyrimidine nucleoside analog that is used in the treatment of colorectal cancer. It is a potent inhibitor of DNA polymerase and other enzymes involved in DNA replication and transcription, including RNA polymerase. Trifluridine has been shown to inhibit the growth of various types of human tumor cells in vitro. This drug also has anti-inflammatory properties, which may be due to its ability to inhibit prostaglandin synthesis. Trifluridine can cause fetal bovine syndrome when given to pregnant women and should not be used during pregnancy or breastfeeding.</p>Formula:C9H11ClN4O2·HClPurity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:279.12 g/molTipiracil Hydrochloride
CAS:Controlled Product<p>Applications Tipiracil Hydrochloride serves as a treatment for metastatic colorectal cancer (mCRC). A thymidine phosphorylase inhibitor.<br>References Sugita, K., et al.: Oncol., 91, 224-230 (2016); van der Velden, D. L., et al.: Clin. Cancer Res., 22, 2835-2839 (2016)<br></p>Formula:C9H11ClN4O2·(HCl)Color and Shape:White To Off-WhiteMolecular weight:242.66 + (36.46)
![5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione monohydrochloride](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb%2FFC126316.jpg&w=3840&q=75)
