CAS 183204-74-2

Tipiracil

Description:

Tipiracil is a chemical compound primarily recognized for its role as a pharmacological agent in cancer treatment. It functions as a thymidine phosphorylase inhibitor, which enhances the efficacy of certain chemotherapeutic agents, particularly in the context of colorectal cancer. The compound is often used in combination with trifluridine, a nucleoside analog, to improve therapeutic outcomes. Tipiracil is characterized by its ability to prevent the breakdown of trifluridine, thereby increasing its availability and effectiveness against tumor cells. The substance is typically administered orally and is part of a regimen designed to target rapidly dividing cancer cells. Its mechanism of action involves the inhibition of the enzyme that would otherwise degrade the active drug, allowing for sustained pharmacological activity. As with many cancer therapies, the use of Tipiracil may be associated with side effects, which can include gastrointestinal disturbances and hematological changes. Overall, Tipiracil represents a significant advancement in the field of oncology, particularly for patients with specific types of malignancies.

Formula: C₉H₁₁ClN₄O₂

InChI: InChI=1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16)

InChI key: InChIKey=QQHMKNYGKVVGCZ-UHFFFAOYSA-N

SMILES: C(C1=C(Cl)C(=O)NC(=O)N1)N2C(=N)CCC2

Synonyms:

• 5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione
• MA 1 (pharmaceutical)
• TPI (thymidine phosphorylase inhibitor)
• Tipiracil
• 2,4(1H,3H)-Pyrimidinedione, 5-chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-

2,4(1H,3H)-Pyrimidinedione, 5-chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-

CAS: 183204-74-2

Formula: C₉H₁₁ClN₄O₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 242.6622

Ref: IN-DA0027EV

5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione

CAS: 183204-74-2

5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione

Purity: 99%

Molecular weight: 242.67g/mol

Ref: 54-OR1066781

Tipiracil

CAS: 183204-74-2

Tipiracil inhibits thymidine phosphorylase, enhancing trifluridine bioavailability, and is studied in colorectal and gastric cancer treatment.

Formula: C₉H₁₁ClN₄O₂

Purity: 99.815%

Color and Shape: Solid

Molecular weight: 242.66

Ref: TM-T60343