CAS 18323-44-9

Clindamycin

Description:

Clindamycin is a lincosamide antibiotic that is primarily used to treat various bacterial infections, particularly those caused by anaerobic bacteria and certain protozoa. It is effective against Gram-positive bacteria, including some strains of Staphylococcus and Streptococcus. Clindamycin works by inhibiting bacterial protein synthesis, thereby preventing the growth and reproduction of bacteria. The chemical formula for clindamycin is C18H33ClN2O5S, and it has a molecular weight of approximately 406.99 g/mol. It is typically administered orally or intravenously and is available in various formulations, including capsules, topical solutions, and injectable forms. Clindamycin is known for its good tissue penetration, making it particularly useful in treating skin and soft tissue infections. However, it can also lead to side effects, such as gastrointestinal disturbances and, in rare cases, Clostridium difficile-associated diarrhea. Due to its mechanism of action and spectrum of activity, clindamycin is often used as an alternative for patients allergic to penicillin.

Formula: C₁₈H₃₃ClN₂O₅S

InChI: InChI=1S/C18H33ClN2O5S/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25)/t9-,10+,11-,12+,13-,14+,15+,16+,18+/m0/s1

InChI key: InChIKey=KDLRVYVGXIQJDK-AWPVFWJPSA-N

SMILES: [C@@H](NC(=O)[C@@H]1C[C@@H](CCC)CN1C)([C@H](C)Cl)[C@]2(O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O)[H]

Synonyms:

• (2S,4R)-N-[2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyl-tetrahydropyran-2-yl]propyl]-1-methyl-4-propyl-pyrrolidine-2-carboxamide
• 7(S)-Chloro-7-deoxylincomycin
• 7-Cdl
• 7-Chloro-7-deoxylincomycin
• 7-Chlorolincomycin
• 7-Deoxy-7(S)-chlorolincomycin
• <span class="text-smallcaps">L</smallcap>-threo-<smallcap>D</smallcap>-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-4-propyl-<smallcap>L</span>-2-pyrrolidinecarboxamido)-1-thio-, trans- α-
• <span class="text-smallcaps">L</smallcap>-threo-α-<smallcap>D</span>-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, (2S-trans)-
• <span class="text-smallcaps">L</smallcap>-threo-α-<smallcap>D</span>-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-
• Antirobe
• Chlolincocin
• Cleocin
• Clincin
• ClindaDerm
• Clindam
• Clindamicina
• Clindamycine
• Clinimycin
• Dalacin C
• Dalacin V
• Dalacine
• Klimicin
• Klindan 300
• L-threo-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-, trans- α-
• L-threo-α-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, (2S-trans)-
• L-threo-α-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-
• Methyl (7xi)-7-chloro-6,7,8-trideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-glycero-alpha-D-galacto-octopyranoside
• Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-<span class="text-smallcaps">L</smallcap>-threo-α-<smallcap>D</span>-galacto-octopyranoside
• Sobelin
• U 21251
• methyl (5xi)-7-chloro-6,7,8-trideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-L-glycero-alpha-D-galacto-octopyranoside hydrochloride
• methyl 7-chloro-6,7,8-trideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-L-threo-alpha-D-galacto-octopyranoside
• methyl 7-chloro-6,7,8-trideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-beta-L-arabino-octopyranoside hydrochloride
• Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-L-threo-α-D-galacto-octopyranoside

Clindamycin Hydrochloride Monohydrate

CAS: 18323-44-9, 21462-39-5, 58207-19-5

Formula: C₁₈H₃₃ClN₂O₅S·HCl·H₂O

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 479.46

Ref: 3B-C2256

Clindamycin (Clindamycin Phosphate EP Impurity E)

CAS: 18323-44-9

Formula: C₁₈H₃₃ClN₂O₅S

Molecular weight: 424.98

Ref: 4Z-C-5039

Clindamycin

CAS: 18323-44-9

Clindamycin

Purity: ≥98%

Molecular weight: 424.98g/mol

Ref: 54-BUP13892

Clindamycin

CAS: 18323-44-9

Clindamycin is a semisynthetic antibiotic that blocks bacterial protein synthesis by detaching peptidyl-tRNA from ribosomes.

Formula: C₁₈H₃₃ClN₂O₅S

Purity: 98.04% - 99.87%

Color and Shape: Yellow Amorphous Solid Solid

Molecular weight: 424.98

Ref: TM-T6447

Clindamycin Pyrophosphate Triethylamine Salt

Controlled Product

CAS: 18323-44-9

Stability Hygroscopic
Applications Clindamycin Pyrophosphate is an impurity of Clindamycin (C580000, HCl salt) which is a semi-synthetic antibiotic prepared from Lincomycin.
References Birkenmeyer, R.D., et al.: J. Med. Chem., 13, 616 (1970), Oesterling, et al.: J. Pharm. Sci., 59, 63 (1970), Gray, J.E., et al.: Toxicol. Appl. Pharmacol., 21, 516 (1972), Brown, L.W., et al.: Anal. Profiles Drug Subs., 10, 75 (1981),

Formula: C₁₈H₃₅ClN₂O₁₁P₂SxC₆H₁₅N

Color and Shape: Neat

Molecular weight: 584.94

Ref: TR-C580090

Clindamycin

CAS: 18323-44-9

Applications Clindamycin is a semi-synthetic antibiotic. Antibacterial.
References Birkenmeyer, R.D., et al.: J. Med. Chem., 13, 616 (1970); Oesterling, et al.: J. Pharm. Sci., 59, 63 (1970); Gray, J.E., et al.: Toxicol. Appl. Pharmacol., 21, 516 (1972); Brown, L.W., et al.: Anal. Profiles Drug Subs., 10, 75 (1981);

Formula: C₁₈H₃₃ClN₂O₅S

Color and Shape: Neat

Molecular weight: 424.98

Ref: TR-C580115

Clindamycin

CAS: 18323-44-9

Inhibitor of protein synthesis; lincosamide class

Formula: C₁₈H₃₃ClN₂O₅S

Purity: Min. 95%

Molecular weight: 424.98 g/mol

Ref: 3D-AC34039

Clindamycin Phosphate EP Impurity E

CAS: 18323-44-9

Formula: C₁₈H₃₃ClN₂O₅S

Molecular weight: 424.98

Ref: ST-EA-CP-C26005