CAS 183232-66-8

1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide

Description:

1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide, with the CAS number 183232-66-8, is a synthetic organic compound characterized by its complex structure, which includes a pyrazole core substituted with various aromatic and heterocyclic groups. This compound features a dichlorophenyl group and an iodophenyl group, contributing to its potential biological activity. The presence of a piperidine moiety suggests possible interactions with biological targets, making it of interest in medicinal chemistry. The carboxamide functional group may enhance solubility and stability, while the methyl group can influence the compound's lipophilicity. Overall, this compound's unique structural features may confer specific pharmacological properties, making it a candidate for further investigation in drug development or as a research tool in biochemical studies. However, detailed studies on its biological activity, toxicity, and pharmacokinetics would be necessary to fully understand its potential applications.

Formula: C₂₂H₂₁Cl₂IN₄O

InChI: InChI=1/C22H21Cl2IN4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-7-16(23)13-18(19)24)21(14)15-5-8-17(25)9-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30)

InChI key: InChIKey=BUZAJRPLUGXRAB-UHFFFAOYSA-N

SMILES: CC1=C(N(N=C1C(NN2CCCCC2)=O)C3=C(Cl)C=C(Cl)C=C3)C4=CC=C(I)C=C4

Synonyms:

• 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide
• 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide
• 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide
• 1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-
• AM 251 (pharmaceutical)
• Am 251
• N-(Piperidin-1-Yl)-5-(4-Iodophenyl)-1-(2,4-Dichlorophenyl)-4-Methyl-1H-Pyrazole-3-Carboxamide
• AM251;AM-251
• 1-(2,4-DICHLOROPHENYL)-5-(4-IODOPHENYL)-4-METHYL-N-1-PIPERIDINYL-1 H-PYRAZOLE-3-CARBOXAMIDE
• AM 251 NEW
• AM AM
• CS-985
• 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide AM251

AM 251

CAS: 183232-66-8

Formula: C₂₂H₂₁Cl₂IN₄O

Purity: >97.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 555.24

Ref: 3B-A3151

1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide

CAS: 183232-66-8

Formula: C₂₂H₂₁Cl₂IN₄O

Purity: 98%

Color and Shape: Solid

Molecular weight: 555.2388

Ref: IN-DA0027FI

AM251

CAS: 183232-66-8

Formula: C₂₂H₂₁N₄OCl₂I

Purity: ≥ 98%

Color and Shape: White to off-white or faint beige powder

Molecular weight: 555.24

Ref: 7W-GK6657

AM251

CAS: 183232-66-8

AM251: potent CB1 blocker (IC50: 8 nM), 306x CB2 selective; GPR55 activator (EC50: 39 nM).

Formula: C₂₂H₂₁Cl₂IN₄O

Purity: 97.43% - 98.79%

Color and Shape: A Crystalline Solid

Molecular weight: 555.24

Ref: TM-T1915

AM 251

Controlled Product

CAS: 183232-66-8

Applications AM-251 is a biarylpyrazole compound that acts as an inverse CB1 cannabinoid receptor agonist and a selective GPR55 agonist.
References Kesser, C., et al.: Mol. Cell. Endocrinol., 302, 108 (2009), Araujo, J., et al.: Pharmacol., 83, 170 (2009), Malysz, J., et al.: Eur. J. Pharmacol., 603, 12 (2009),

Formula: C₂₂H₂₁Cl₂IN₄O

Color and Shape: Neat

Molecular weight: 555.24

Ref: TR-A575805

AM 251

Controlled Product

CAS: 183232-66-8

Cannabinoid receptor CB1 inverse antagonist with IC50 = 8 nM. It inhibits cocaine-primed relapse and reduction of daily food intake in rats. Was also shown to up-regulate EGFR expression via a non-CB1-mediated pathway.

Formula: C₂₂H₂₁Cl₂IN₄O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 555.24 g/mol

Ref: 3D-BA17338