CAS 183320-51-6

Desmethyl Erlotinib

Description:

Desmethyl Erlotinib, with the CAS number 183320-51-6, is a chemical compound that serves as a metabolite of Erlotinib, an anticancer drug primarily used in the treatment of non-small cell lung cancer and pancreatic cancer. This compound is characterized by its structure, which is similar to that of Erlotinib but lacks a methyl group, influencing its pharmacological properties. Desmethyl Erlotinib exhibits a mechanism of action that involves the inhibition of the epidermal growth factor receptor (EGFR) tyrosine kinase, thereby interfering with cancer cell proliferation and survival. The compound is typically studied for its role in drug metabolism and pharmacokinetics, as well as its potential therapeutic effects. In terms of solubility, it is generally soluble in organic solvents, which is common for many small organic molecules. Understanding the characteristics of Desmethyl Erlotinib is crucial for evaluating its efficacy and safety profile in clinical settings, particularly in relation to its parent compound, Erlotinib.

Formula: C₂₁H₂₁N₃O₄.HCl

Synonyms:

• 2-[[4-[(3-Ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]ethanol hydrochloride
• Osi 420
• Ethanol, 2-[[4-[(3-ethynylphenyl)aMino]-7-(2-Methoxyethoxy)-6-quinazolinyl]oxy]-, hydrochloride
• OSI-420 (DesMethyl Erlotinib,CP-473420)
• Cp-473420
• OSI-420 hydrochloride

Desmethyl Erlotinib (hydrochloride)

CAS: 183320-51-6

Formula: C₂₁H₂₂ClN₃O₄

Purity: 98%

Molecular weight: 415.8701

Ref: IN-DA0027I1

Desmethyl Erlotinib hydrochloride

CAS: 183320-51-6

Desmethyl Erlotinib hydrochloride

Purity: ≥98%

Molecular weight: 415.87g/mol

Ref: 54-BUP02997

Erlotinib O-Desmethyl Metabolite Isomer (M14) HCl

CAS: 183320-51-6

Formula: C₂₁H₂₁N₃O₄·HCl

Color and Shape: Brown Solid

Molecular weight: 379.42 36.46

Ref: 4Z-E-2810

Desmethyl Erlotinib hydrochloride

CAS: 183320-51-6

Desmethyl Erlotinib hydrochloride (OSI 420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor.

Formula: C₂₁H₂₁N₃O₄·HCl

Purity: 99.49%

Color and Shape: Solid

Molecular weight: 415.87

Ref: TM-T6619

OSI-420

CAS: 183320-51-6

OSI-420 is an antibody that selectively binds to epidermal growth factor receptor (EGFR). It is a monoclonal antibody, which is a protein produced by the immune system in response to a specific antigen. The binding of OSI-420 to the EGFR causes the receptor to become inactive, preventing it from signaling for cell proliferation. OSI-420 has been shown to be effective against malignant brain tumors and may be used as a diagnostic aid. This drug also has therapeutic potential for diabetic patients, as it has been shown to reduce blood glucose levels when administered with insulin.

Formula: C₂₁H₂₁N₃O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 379.41 g/mol

Ref: 3D-FO158697

Ethanol, 2-[[4-[(3-ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]-, hydrochloride (1:1)

CAS: 183320-51-6

Purity: ≥98%

Molecular weight: 415.8699951

Ref: 10-F865801

Desmethyl Erlotinib Hydrochloride

CAS: 183320-51-6

Formula: C₂₁H₂₁N₃O₄HCl

Molecular weight: 379.42 : 36.46

Ref: ST-EA-CP-E17013