CAS 183506-66-3: APICIDIN

Description: Apicidin is a chemical compound known for its role as a histone deacetylase (HDAC) inhibitor, which is significant in the field of cancer research and epigenetics. It is derived from the natural product of the fungus *Fusarium* and has garnered attention for its potential therapeutic applications. Apicidin exhibits a unique structure that allows it to interact with the enzyme HDAC, leading to the modulation of gene expression. This modulation can result in the induction of cell cycle arrest and apoptosis in cancer cells, making it a candidate for anticancer drug development. Additionally, Apicidin has been studied for its effects on various cellular processes, including differentiation and proliferation. Its mechanism of action involves the alteration of acetylation status of histones, which can influence chromatin structure and gene accessibility. While promising, further research is necessary to fully understand its efficacy, safety, and potential side effects in clinical settings.

Formula: C₃₄H₄₉N₅O₆

InChI: InChI=1/C34H49N5O6/c1-5-22(3)30-34(44)38-19-13-12-18-29(38)33(43)35-26(16-9-7-8-14-24(40)6-2)31(41)36-27(32(42)37-30)20-23-21-39(45-4)28-17-11-10-15-25(23)28/h10-11,15,17,21-22,26-27,29-30H,5-9,12-14,16,18-20H2,1-4H3,(H,35,43)(H,36,41)(H,37,42)/t22-,26-,27-,29+,30-/m0/s1

Synonyms:

• Cyclo-L-(2-Amino-8-Oxodeacanoyl)-L-(N-Methoxy-Tryptophan)-L-Isoleucyl-D-Pipecolinyl
• Cyclo-[L-(2-Amino-8-Oxodecanoyl)-L-(N-Methoxytryptophan)-L-Isoleucyl-D-Pipecolinyl
• Cyclo[(2S)-2-Amino-8-Oxodecanoyl-1-Methoxy-L-Tryptophyl-L-Isoleucyl-(2R)-2-Piperidinexcarbonyl]
• Apicidin, Fusarium Species
• (3S,6S,9S,15aR)-6-[(1-methoxy-1H-indol-3-yl)methyl]-9-[(1S)-1-methylpropyl]-3-(6-oxooctyl)octahydro-2H-pyrido[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10(3H,12H)-tetrone

Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]

CAS: 183506-66-3

• Formula: C₃₄H₄₉N₅O₆
• Purity: 99.68%
• Color and Shape: Solid
• Molecular weight: 623.7828

Apicidin

CAS: 183506-66-3

• Formula: C₃₃H₄₇N₅O₆
• Purity: By hplc: 99.12% (Typical Value in Batch COA)
• Color and Shape: white powder
• Molecular weight: 609.76g/mol

Apicidin

CAS: 183506-66-3

Apicidin (OSI 2040) is a histone deacetylase (HDAC) inhibitor with antiparasitic activity and antiproliferative activity …

• Formula: C₃₄H₄₉N₅O₆
• Purity: 99.68%
• Color and Shape: Solid
• Molecular weight: 623.78

Apicidin

CAS: 183506-66-3

• Formula: C₃₄H₄₉N₅O₆
• Purity: ≥ 98.0%
• Color and Shape: White or almost white solid
• Molecular weight: 623.78

Apicidin

CAS: 183506-66-3

Apicidin is a cyclic peptide that is structurally similar to the natural antibiotic apigenin. It …

• Formula: C₃₄H₄₉N₅O₆
• Purity: Min. 95%
• Molecular weight: 623.78 g/mol