CAS 18361-46-1
:Leucomycin A4
Description:
Leucomycin A4 is a macrolide antibiotic that is derived from the fermentation of the bacterium *Streptomyces aureofaciens*. It is characterized by its complex structure, which includes a large lactone ring and several sugar moieties that contribute to its biological activity. This compound exhibits antibacterial properties, particularly against Gram-positive bacteria, making it useful in clinical settings for treating various infections. Leucomycin A4 is known for its mechanism of action, which involves inhibiting bacterial protein synthesis by binding to the 50S ribosomal subunit. This interference disrupts the translation process, ultimately leading to the cessation of bacterial growth. The compound is typically administered in its salt form and has been studied for its pharmacokinetics, including absorption, distribution, metabolism, and excretion. Additionally, it is important to note that while Leucomycin A4 is effective against certain pathogens, resistance can develop, necessitating careful consideration in its therapeutic use. Overall, Leucomycin A4 represents a significant class of antibiotics with a specific role in combating bacterial infections.
Formula:C41H67NO15
InChI:InChI=1/C41H67NO15/c1-11-15-31(46)55-39-26(5)52-33(22-41(39,7)49)56-36-25(4)53-40(35(48)34(36)42(8)9)57-37-28(18-19-43)20-23(2)29(45)17-14-12-13-16-24(3)51-32(47)21-30(38(37)50-10)54-27(6)44/h12-14,17,19,23-26,28-30,33-40,45,48-49H,11,15-16,18,20-22H2,1-10H3/b13-12+,17-14+/t23-,24-,25-,26+,28+,29+,30-,33+,34-,35-,36-,37+,38+,39+,40+,41-/m1/s1
InChI key:InChIKey=XVTMRUKLMXPAKO-RXUUKHTDSA-N
SMILES:O([C@@H]1[C@@H](OC)[C@H](OC(C)=O)CC(=O)O[C@H](C)C\C=C\C=C\[C@H](O)[C@H](C)C[C@@H]1CC=O)[C@H]2[C@H](O)[C@@H](N(C)C)[C@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(CCC)=O)[C@H](C)O3)[C@@H](C)O2
Synonyms:- Oxacyclohexadecane, leucomycin V deriv.
- Leucomycin V, 3-acetate 4B-butanoate
- Leucomycin A4
- Leukomycin A4
- (4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-(Acetyloxy)-6-[[3,6-dideoxy-4-O-(2,6-dideoxy-4-O-butanoyl-3-C-methyl-α-L-ribo-hexopyranosyl)-3-(dimethylamino)-β-D-glucopyranosyl]oxy]-10-hydroxy-5-methoxy-9,16-dimethyl-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-2-one
- Leucomycin V 3-acetate 4''-butanoate
- KitasaMycin A4
- See more synonyms
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Found 5 products.
Leucomycin A4
CAS:<p>Leucomycin A4, a macrolide from S. kitasatoensis, fights S. aureus, B. subtilis, C. diphtheriae, N. gonorrhoeae, H. influenzae. MICs: 0.15-1.25 μg/ml.</p>Formula:C41H67NO15Color and Shape:SolidMolecular weight:813.979Leucomycin A4
CAS:Formula:C41H67NO15Purity:≥ 95.0%Color and Shape:Lyophilised solidMolecular weight:814
