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CAS 183814-30-4

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Formoterol fumarate dihydrate

Description:
Formoterol fumarate dihydrate is a long-acting beta-2 adrenergic agonist primarily used in the management of asthma and chronic obstructive pulmonary disease (COPD). It is characterized by its ability to relax bronchial smooth muscle, leading to bronchodilation and improved airflow. The substance is a white to off-white crystalline powder, soluble in water, and has a molecular formula that reflects its dihydrate form, indicating the presence of water molecules in its crystalline structure. Formoterol fumarate dihydrate exhibits a prolonged duration of action, typically lasting up to 12 hours, which makes it suitable for both maintenance and rescue therapy in respiratory conditions. Its pharmacokinetics involve rapid absorption and a relatively high bioavailability when administered via inhalation. Additionally, it is often combined with corticosteroids to enhance therapeutic efficacy and reduce inflammation in the airways. As with any medication, it is essential to monitor for potential side effects, including cardiovascular effects and paradoxical bronchospasm.
Formula:C23H32N2O10
InChI:InChI=1/C19H24N2O4.C4H4O4.2H2O/c1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22;5-3(6)1-2-4(7)8;;/h3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22);1-2H,(H,5,6)(H,7,8);2*1H2/b;2-1+;;/t13-,19+;;;/m1.../s1
Synonyms:
  • (R*,R*)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide fumarate dihydrate
  • N-{2-hydroxy-5-[(1R)-1-hydroxy-2-{[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino}ethyl]phenyl}formamide (2E)-but-2-enedioate hydrate (1:1:2)
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