CAS 184036-34-8

Sitaxentan

Description:

Sitaxentan is a selective endothelin receptor antagonist primarily used in the treatment of pulmonary arterial hypertension (PAH). It functions by blocking the action of endothelin-1, a potent vasoconstrictor, thereby promoting vasodilation and reducing blood pressure in the pulmonary arteries. The chemical formula of sitaxentan is C21H26N2O3S, and it features a sulfonamide group, which contributes to its pharmacological activity. Sitaxentan is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. Its efficacy in improving exercise capacity and delaying clinical worsening in PAH patients has been demonstrated in clinical trials. However, it is important to note that sitaxentan has been associated with liver toxicity, leading to its withdrawal from the market in some regions. As with any medication, monitoring for side effects and contraindications is essential when considering its use in clinical practice. Overall, sitaxentan represents a significant advancement in the management of pulmonary arterial hypertension, although its safety profile necessitates careful consideration.

Formula: C₁₈H₁₅ClN₂O₆S₂

InChI: InChI=1/C18H17ClN2O6S2/c1-10-5-13-14(27-9-26-13)7-11(10)6-12(22)16-15(3-4-28-16)29(23,24)20-18-17(19)21(2)8-25-18/h3-5,7,20H,6,8-9H2,1-2H3

InChI key: InChIKey=PHWXUGHIIBDVKD-UHFFFAOYSA-N

SMILES: C(CC=1C=C2C(=CC1C)OCO2)(=O)C3=C(S(NC4=C(Cl)C(C)=NO4)(=O)=O)C=CS3

Synonyms:

• 3-Thiophenesulfonamide, N-(4-chloro-3-methyl-5-isoxazolyl)-2-((6-methyl-1,3-benzodioxol-5-yl)acetyl)-
• 3-Thiophenesulfonamide, N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]-
• Ipi 1040
• N-(4-Chloro-3-methyl-1,2-oxazol-5-yl)-2-[2-(6-methyl-2H-1,3-benzodioxol-5-yl)acetyl]thiophene-3-sulfonamide
• N-(4-Chloro-3-methyl-5-isoxazolyl)-2-((2-methyl-4,5-methylenedioxyphenyl)acetyl)thiophene-3-sulfonamide
• N-(4-Chloro-3-methyl-5-isoxazolyl)-2-((3,4-(methylenedioxy)-6-methylphenyl)acetyl)-3-thiophenesulfonamide
• N-(4-Chloro-3-methyl-5-isoxazolyl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]-3-thiophenesulfonamide
• N-(4-chloro-3-methyl-2H-oxazol-5-yl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]thiophene-3-sulfonamide
• Sitax
• Sitaxentan
• Tbc 11251
• IPI-1040;SITAXENTAN;TBC-11251
• N- (4- chloro- 3- Methyl- oxazol- 5- yl)- 2- [2- (6- Methylbenzo[1,3]dioxol- 5- yl)acetyl]- thiophen
• N-(4-Chloro-3-methyl-oxazol-5-yl)-2-[2-(6-methylbenzo[1,3]dioxol-5-yl)acetyl]thiophene-3-sulfo
• N-(4-Chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d]-[1,3]dioxol-5-yl)acetyl)thiophene-3
• N-(4-CHLORO-3-METHYL-1,2-OXAZOL-5-YL)-2-[2-(6-METHYL-1,3-BENZODIOXOL-5-YL)ACETYL]THIOPHENE-3-SULFONAMIDE
• N-(4-chloro-3-methyl-2,3-dihydrooxazol-5-yl)-2-(2-(6-methylbenzo[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide
• sitaxsentan, CID216235
• D07171
• N-(4-chloro-3-methyl-oxazol-5-yl)-2-[2-(6-methylbenzo[1,3]dioxol-5-yl)acetyl]thiophene-3-sulfonamide
• N-(4-Chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1 ,3]dioxol-5-yl)acetyl)thiophene-3-su
• (210421-64-0) sitaxsentan

N-(4-chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide

CAS: 184036-34-8

Formula: C₁₈H₁₅ClN₂O₆S₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 454.9045

Ref: IN-DA0039V5

Sitaxsentan

CAS: 184036-34-8

Sitaxsentan

Purity: ≥95%

Molecular weight: 454.9g/mol

Ref: 54-BUP08894

Sitaxsentan

CAS: 184036-34-8

Sitaxsentan (TBC-11251), a selective ETA receptor antagonist, prevents vasoconstriction by blocking endothelin.

Formula: C₁₈H₁₅ClN₂O₆S₂

Purity: 97.99% - 98.71%

Color and Shape: Solid

Molecular weight: 454.9

Ref: TM-T12924