CAS 18417-89-5

Sangivamycin

Description:

Sangivamycin is a nucleoside analog with notable antitumor properties, primarily derived from the bacterium *Sanguibacterium* species. It exhibits a unique structure that allows it to interfere with nucleic acid synthesis, making it a potential candidate for cancer therapy. The compound is characterized by its ability to inhibit DNA and RNA synthesis, which is crucial for the proliferation of cancer cells. Sangivamycin has shown activity against various cancer cell lines in preclinical studies, indicating its potential effectiveness in oncology. Additionally, it has been investigated for its antiviral properties, particularly against certain viruses. The compound's mechanism of action involves incorporation into nucleic acids, leading to disruption of normal cellular processes. However, like many chemotherapeutic agents, it may also exhibit toxicity, necessitating careful consideration of dosing and administration in clinical settings. Overall, Sangivamycin represents a significant area of research in the development of novel anticancer and antiviral therapies.

Formula: C₁₂H₁₅N₅O₅

InChI: InChI=1S/C12H15N5O5/c13-9-6-4(10(14)21)1-17(11(6)16-3-15-9)12-8(20)7(19)5(2-18)22-12/h1,3,5,7-8,12,18-20H,2H2,(H2,14,21)(H2,13,15,16)/t5-,7-,8-,12-/m1/s1

InChI key: InChIKey=OBZJZDHRXBKKTJ-JTFADIMSSA-N

SMILES: O[C@H]1[C@H](N2C=3C(C(C(N)=O)=C2)=C(N)N=CN3)O[C@H](CO)[C@H]1O

Synonyms:

• 4-Amino-7-β-<span class="text-smallcaps">D</span>-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide
• 4-amino-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide
• 4-amino-7-pentofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide
• 4-amino-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide hydrate
• 7-Deazaadenosine-7-carboxamide
• 7H-Pyrrolo[2,3-d]pyrimidine-5-carboxamide, 4-amino-7-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• NSC 65346
• Sangivamycin
• 4-Amino-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide
• 7H-Pyrrolo[2,3-d]pyrimidine-5-carboxamide, 4-amino-7-β-D-ribofuranosyl-

Sangivamycin

CAS: 18417-89-5

Sangivamycin

Purity: ≥98%

Molecular weight: 309.28g/mol

Ref: 54-BUP03105

Sangivamycin

CAS: 18417-89-5

Sangivamycin (NSC-65346) inhibits PKC (Ki=10μM) and hinders growth in various human cancers.

Formula: C₁₂H₁₅N₅O₅

Purity: 99.85%

Color and Shape: Solid

Molecular weight: 309.28

Ref: TM-T9605

Sangivamycin hydrate

CAS: 18417-89-5

Formula: C₁₂H₁₅N₅O₅·xH₂O

Molecular weight: 309.28 (anhydrous)

Ref: 7W-GA6883

Sangivamycin

CAS: 18417-89-5

Sangivamycin is a nucleoside analog with action as a protein kinase C inhibitor and is used for research on antiviral and anticancer therapies.

Formula: C₁₂H₁₅N₅O₅

Purity: Min. 97 Area-%

Color and Shape: Powder

Molecular weight: 309.28 g/mol

Ref: 3D-AS181128

Sangivamycin

Controlled Product

CAS: 18417-89-5

Stability Hygroscopic
Applications Sangivamycin is a cytotoxic purine nucleoside.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wakao, K. et al.: Biochem. Biophys. Res. Comm., 444, 135 (2014);

Formula: C₁₂H₁₅N₅O₅

Color and Shape: Neat

Molecular weight: 309.28

Ref: TR-S112503