CAS 18439-24-2

coenzyme A trilithium salt

Description:

Coenzyme A trilithium salt, identified by the CAS number 18439-24-2, is a salt form of coenzyme A, which is a crucial cofactor in various biochemical reactions, particularly in the metabolism of fatty acids and the synthesis of acetyl-CoA. This compound is characterized by its high solubility in water due to the presence of lithium ions, which enhances its stability and bioavailability in biological systems. Coenzyme A itself is a complex molecule that contains an adenosine moiety, a pantothenic acid derivative, and a mercaptoethylamine group, allowing it to participate in acyl group transfers. The trilithium salt form is particularly useful in laboratory settings for studying enzymatic reactions and metabolic pathways. Its ionic nature may influence its interaction with other biomolecules, potentially affecting its role in enzymatic processes. Overall, coenzyme A trilithium salt serves as an important tool in biochemistry and molecular biology, facilitating research into metabolic functions and enzyme kinetics.

Formula: C₂₁H₃₃Li₃N₇O₁₆P₃S

InChI: InChI=1/C21H36N7O16P3S.3Li/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;;;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35);;;/q;3*+1/p-3/t11-,14-,15-,16+,20-;;;/m1.../s1

InChI key: InChIKey=INHFHKVLIJCQLE-FFKZSOHASA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](COP(OP(OCC([C@H](C(NCCC(NCCS)=O)=O)O)(C)C)(=O)O)(=O)O)[C@H]1OP(=O)(O)O.[Li]

Synonyms:

• CoA trilithium salt
• Coenzyme A, lithium salt (1:3)
• Coenzymelithiumsalt
• Coenzyme�A trilithium salt
• Trilithium coenzyme A
• adenosine, 5'-O-[hydroxy[[hydroxy[[(3R)-3-hydroxy-4-[[3-[(2-mercaptoethyl)amino]-3-oxopropyl]amino]-2,2-dimethyl-4-oxobutyl]oxy]phosphinyl]oxy]phosphinyl]-, 3'-(dihydrogen phosphate), lithium salt (1:3)
• coenzyme A lithium from yeast
• Coenzyme A, trilithium salt
• CoenzymeATrilithiumSal
• COENZYME A (LITHIUM SALT);COENZYME A (LI SALT)
• COENZYME A, DILITHIUM
• COA LI3
• Einecs 242-317-9
• Coenzyme A (Li salt)
• COENZYME A TRILITHIUM SALT extrapure
• Coenzym A, Trilithiumsalz
• Coenzyme A Trilithium Salt from Yeast
• Native Yeast Coenzyme A, Trilithium Salt
• COENZYME A LITHIUM SALT
• COENZYME A, TRILITHIUM
• Coenzyme A, Trilithium Salt - CAS 18439-24-2 - Calbiochem
• Coenzyme A Trilithium Salt ex. Yeast extrapure, 90% CoA
• 1-(3-Bromo-5-methylpyridin-2-yl)-4-propylpiperazine
• COENZYME A, LITHIUM SALT HYDRATE
• Coenzyme A Trilithium Salt, from Yeast(CoA-Li)
• Coenzyme A (trilithium salt) 500mg

Coenzyme A trilithium salt, 95%

CAS: 18439-24-2

Useful for fatty acid synthesis and oxidation

Formula: C₂₁H₃₃Li₃N₇O₁₆P₃S

Purity: 95%

Color and Shape: Pale cream to pale yellow, Lyophilized powder

Molecular weight: 785.33

Ref: 02-J65434

Coenzyme A trilithium salt

CAS: 18439-24-2

Coenzyme A trilithium salt

Formula: C₂₁H₃₃N₇O₁₆P₃S·3Li

Purity: ≥ 98%

Color and Shape: Crystals

Molecular weight: 785.3333g/mol

Ref: 54-BIC7401

Coenzyme A Li salt

CAS: 18439-24-2

Formula: C21H36N7O16P3S.3Li

Purity: >98%

Color and Shape: Solid

Molecular weight: 788.36

Ref: 48-19-1010

Coenzyme A trilithium salt

CAS: 18439-24-2

Formula: C₂₁H₃₃Li₃N₇O₁₆P₃S

Purity: ≥ 75.0% (enzymatic at pH 7.5)

Color and Shape: White to light-yellow powder

Molecular weight: 785.33

Ref: 7W-GE3164

Coenzyme A Trilithium Salt

CAS: 18439-24-2

Formula: C₂₁H₃₃N₇O₁₆P₃S₃·3Li

Molecular weight: 764.51 3*6.94

Ref: 4Z-C-7112

Coenzyme A Trilithium Salt

CAS: 18439-24-2

Stability Hygroscopic
Applications A cofactor in enzymatic acetyl transfer reactions. It is the source of the phosphopantetheine group that is added as a prosthetic group to proteins such as acyl carrier protein and formyltetrahydrofolate dehydrogenase.
References Strickland K.C. et al.: J. Biol. Chem., 285, 1627 (2010); Elovson J. et al.: J. Biol. Chem., 243, 3603 (1968);

Formula: C₂₁H₃₃N₇O₁₆P₃S·3Li

Color and Shape: Neat

Molecular weight: 785.33

Ref: TR-C636400

Coenzyme A trilithium salt

CAS: 18439-24-2

Coenzyme A trilithium salt is a synthetic cofactor that is used in the synthesis of long-chain fatty acids. It is membrane permeable and has minimal toxicity, making it an attractive candidate for treating hepatic steatosis. Coenzyme A trilithium salt also activates human mitochondrial beta-oxidation by increasing the availability of substrate and enhancing the expression of genes involved in beta-oxidation. This molecule has been shown to be effective in improving the symptoms of X-linked adrenoleukodystrophy (X-ALD) by stimulating creatine kinase activity and suppressing lysosomal accumulation of long chain fatty acids.

Formula: C₂₁H₃₃Li₃N₇O₁₆P₃S

Purity: Min. 80%

Color and Shape: White Off-White Powder

Molecular weight: 785.33 g/mol

Ref: 3D-NC20534

Coenzyme A Trilithium Salt ex. Yeast extrapure, 90% CoA

CAS: 18439-24-2

Formula: C₂₁H₃₃N₇O₁₆P₃SLi₃·2H₂O

Purity: ~ 90%

Color and Shape: White, Crystalline powder

Molecular weight: 821.36

Ref: SR-64147

Coenzyme A (trilithium)

CAS: 18439-24-2

Purity: 98%

Molecular weight: 785.14

Ref: 10-F556572

Coenzyme A, Trilithium salt

CAS: 18439-24-2

Purity: 98%

Molecular weight: 785.14

Ref: 10-C300025

Coenzyme A trilithium salt

CAS: 18439-24-2

Formula: C₂₁H₃₃Li₃N₇O₁₆P₃S

Purity: 75%

Color and Shape: Solid

Molecular weight: 785.3333

Ref: IN-DA00JKIC