CAS 184475-35-2: Gefitinib

Description:Gefitinib is a small molecule tyrosine kinase inhibitor primarily used in the treatment of non-small cell lung cancer (NSCLC) that harbors specific mutations in the epidermal growth factor receptor (EGFR). Its chemical formula is C22H24ClFN4O3, and it features a complex structure that includes a quinazoline core. Gefitinib works by selectively inhibiting the tyrosine kinase activity of the EGFR, thereby blocking downstream signaling pathways that promote cell proliferation and survival. This mechanism of action makes it particularly effective in tumors with activating mutations in the EGFR gene. Gefitinib is administered orally and is characterized by its moderate solubility in water and its ability to penetrate biological membranes, which is crucial for its therapeutic efficacy. Common side effects associated with gefitinib include skin rash, diarrhea, and liver enzyme elevations. Its pharmacokinetics are influenced by factors such as food intake and liver function, necessitating careful monitoring during treatment. Overall, gefitinib represents a targeted therapy that has significantly improved outcomes for patients with specific types of lung cancer.

Formula:C₂₂H₂₄ClFN₄O₃

InChI:InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)

InChI key:InChIKey=XGALLCVXEZPNRQ-UHFFFAOYSA-N

SMILES:FC1=CC=C(C=C1Cl)NC=2N=CN=C3C=C(OC)C(OCCCN4CCOCC4)=CC32

Synonyms:
(3-Chloro-4-fluorophenyl)[7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-yl]amine
4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline
4-(3′-Chloro-4′-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline
4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-
Akos 91371
Gefitinib
Gefitinib Base
Gefitinib(TINIBS)
Gefitinib, Iressa, ZD1839
Gefonib
See more synonyms
Geftinib
N-(3-Chloro-4-Fluoro-Phenyl)-7-Methoxy-6-(3-Morpholin-4-Ylpropoxy)Quinazolin-4-Amine
N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine
N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine
Zd 1839
Zd1839
Iressa

Found 16 products.

Product data	Purity	Price range	Estimated delivery
Gefitinib REF: 3B-G0546CAS: 184475-35-2	>98.0%(T)(HPLC)	39.00 €~126.00 €	Wed 09 Apr 25
Gefitinib CRS REF: 41-Y0001813CAS: 184475-35-2	- - -	115.00 €	Mon 14 Apr 25
Gefitinib for system suitability CRS REF: 41-Y0001809CAS: 184475-35-2	- - -	115.00 €	Mon 14 Apr 25
Gefitinib REF: 45-1289105CAS: 184475-35-2	- - -	638.00 €	Tue 15 Apr 25
N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine REF: IN-DA0039KYCAS: 184475-35-2	98%	27.00 €~557.00 €	Wed 16 Apr 25
Gefitinib REF: TM-T1181CAS: 184475-35-2	100% - 99.92%	54.00 €~145.00 €	Wed 16 Apr 25
Gefitinib REF: 7W-GP9843CAS: 184475-35-2	≥ 99.0%	58.00 €~133.00 €	Thu 17 Apr 25
Gefitinib REF: 4Z-G-231CAS: 184475-35-2	- - -	To inquire	Thu 17 Apr 25
Gefitinib REF: 86-MM3563.00CAS: 184475-35-2	- - -	346.00 €	Mon 21 Apr 25
Gefitinib REF: 54-BISN0101CAS: 184475-35-2	- - -	170.00 €~269.00 €	Wed 23 Apr 25
Gefitinib RS REF: 2K-1055700021CAS: 184475-35-2	- - -	To inquire	Thu 24 Apr 25
N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine REF: 10-F079438CAS: 184475-35-2	95.0%	To inquire	Mon 28 Apr 25
Gefitinib REF: TR-G304000CAS: 184475-35-2	- - -	104.00 €~227.00 €	Mon 28 Apr 25
Gefitinib-d6 REF: TR-G304008CAS: 184475-35-2	- - -	2,508.00 €~5,730.00 €	Mon 28 Apr 25
Gefitinib - Bio-X ™ REF: 3D-BG164498CAS: 184475-35-2	Min. 98 Area-%	147.00 €	Tue 29 Apr 25
Gefitinib REF: 3D-FG10816CAS: 184475-35-2	Min. 98 Area-%	143.00 €~1,026.00 €	Tue 29 Apr 25