CAS 184475-35-2

Gefitinib

Description:

Gefitinib is a small molecule tyrosine kinase inhibitor primarily used in the treatment of non-small cell lung cancer (NSCLC) that harbors specific mutations in the epidermal growth factor receptor (EGFR). Its chemical formula is C22H24ClFN4O3, and it features a complex structure that includes a quinazoline core. Gefitinib works by selectively inhibiting the tyrosine kinase activity of the EGFR, thereby blocking downstream signaling pathways that promote cell proliferation and survival. This mechanism of action makes it particularly effective in tumors with activating mutations in the EGFR gene. Gefitinib is administered orally and is characterized by its moderate solubility in water and its ability to penetrate biological membranes, which is crucial for its therapeutic efficacy. Common side effects associated with gefitinib include skin rash, diarrhea, and liver enzyme elevations. Its pharmacokinetics are influenced by factors such as food intake and liver function, necessitating careful monitoring during treatment. Overall, gefitinib represents a targeted therapy that has significantly improved outcomes for patients with specific types of lung cancer.

Formula: C₂₂H₂₄ClFN₄O₃

InChI: InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)

InChI key: InChIKey=XGALLCVXEZPNRQ-UHFFFAOYSA-N

SMILES: N(C=1C2=C(C=C(OC)C(OCCCN3CCOCC3)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4

Synonyms:

• (3-Chloro-4-fluorophenyl)[7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-yl]amine
• 4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline
• 4-(3′-Chloro-4′-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline
• 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-
• Akos 91371
• Gefitinib
• Gefitinib Base
• Gefitinib(TINIBS)
• Gefitinib, Iressa, ZD1839
• Gefonib
• Geftinib
• N-(3-Chloro-4-Fluoro-Phenyl)-7-Methoxy-6-(3-Morpholin-4-Ylpropoxy)Quinazolin-4-Amine
• N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine
• N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine
• Zd 1839
• Zd1839

N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine

CAS: 184475-35-2

Formula: C₂₂H₂₄ClFN₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 446.91

Ref: 10-F079438

Gefitinib-d6

Controlled Product

CAS: 184475-35-2

Applications Gefitinib-d6 is the labeled version of Gefitinib (G304000), which is an antineoplastic.
References Anderson, N.G., et al.: Int. J. Cancer, 94, 774 (2001), Hirata, A., et al.: Cancer Res., 62, 2554 (2002), Kris, M.G., et al.: J. Am. Med. Assoc., 290, 2149 (2003), Tamura, K., et al.: Expert Opin. Pharmacother., 6, 985 (2005)

Formula: C₂₂D₆H₁₈ClFN₄O₃

Color and Shape: Neat

Molecular weight: 452.939

Ref: TR-G304008

Gefitinib RS

CAS: 184475-35-2

Color and Shape: White Solid Powder

Ref: 2K-1055700021