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CAS 184475-55-6

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Gefitinib hydrochloride

Description:
Gefitinib hydrochloride is a small molecule inhibitor primarily used in the treatment of non-small cell lung cancer (NSCLC) that expresses the epidermal growth factor receptor (EGFR) mutation. It is classified as an anilinoquinazoline derivative and functions by selectively inhibiting the tyrosine kinase activity of the EGFR, thereby blocking downstream signaling pathways that promote cell proliferation and survival. The substance appears as a white to pale yellow crystalline powder and is soluble in organic solvents like dimethyl sulfoxide (DMSO) and methanol, but has limited solubility in water. Its molecular formula includes elements such as carbon, hydrogen, nitrogen, oxygen, and chlorine, reflecting its complex structure. Gefitinib hydrochloride is administered orally and is known for its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, which are crucial for its therapeutic efficacy. Side effects may include skin rashes, diarrhea, and liver function abnormalities, necessitating monitoring during treatment. Overall, gefitinib hydrochloride represents a targeted therapy approach in oncology, emphasizing the importance of personalized medicine in cancer treatment.
Formula:C22H25Cl2FN4O3
InChI:InChI=1/C22H24ClFN4O3.ClH/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15;/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27);1H
SMILES:COc1cc2c(cc1OCCCN1CCOCC1)c(ncn2)Nc1ccc(c(c1)Cl)F.Cl
Synonyms:
  • 4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline hydrochloride
  • N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine hydrochloride
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Found 4 products.