CAS 184475-56-7

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-, hydrochloride (1:2)

Description:

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-, hydrochloride (1:2) is a synthetic organic compound characterized by its complex structure, which includes a quinazoline core substituted with various functional groups. The presence of a chloro and a fluorine atom on the phenyl ring contributes to its potential biological activity, while the methoxy and morpholinyl propoxy groups enhance its solubility and pharmacological properties. This compound is typically utilized in medicinal chemistry research, particularly in the development of pharmaceuticals targeting specific biological pathways. As a hydrochloride salt, it is likely to exhibit improved stability and solubility in aqueous environments, making it suitable for formulation in drug development. The compound's specific interactions with biological targets can be influenced by its stereochemistry and the electronic effects of the substituents, which are critical for its efficacy and safety profile. Overall, this compound represents a class of molecules that may have therapeutic applications, pending further investigation into its biological activity and mechanism of action.

Formula: C₂₂H₂₄ClFN₄O₃·2ClH

InChI: InChI=1S/C22H24ClFN4O3.2ClH/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15;;/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27);2*1H

InChI key: InChIKey=OHAYARNLYSPHOJ-UHFFFAOYSA-N

SMILES: N(C=1C2=C(C=C(OC)C(OCCCN3CCOCC3)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4.Cl

Synonyms:

• 4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline dihydrochloride
• 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-, dihydrochloride
• 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-, hydrochloride (1:2)
• N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine dihydrochloride
• Gefitinib dihydrochloride

Gefitinib dihydrochloride

CAS: 184475-56-7

Gefitinib dihydrochloride: orally active, selective EGFR inhibitor (IC50: 33-54 nM), hinders tumor growth, induces autophagy and apoptosis in cancer research.

Formula: C₂₂H₂₆Cl₃FN₄O₃

Color and Shape: Solid

Molecular weight: 519.82

Ref: TM-T63630