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CAS 1847-63-8

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nafoxidine hydrochloride

Description:
Nafoxidine hydrochloride is a synthetic compound primarily recognized for its use as an antiestrogen in the treatment of hormone-dependent cancers, particularly breast cancer. It functions as a selective estrogen receptor modulator (SERM), influencing estrogen activity in various tissues. The substance appears as a white to off-white crystalline powder and is soluble in water and alcohol, which facilitates its administration in pharmaceutical formulations. Nafoxidine hydrochloride has a molecular formula that reflects its complex structure, which includes a phenolic moiety and a piperidine ring, contributing to its biological activity. The compound's mechanism of action involves binding to estrogen receptors, thereby inhibiting estrogen's proliferative effects on target tissues. While it has shown promise in clinical settings, its use has been overshadowed by other SERMs due to varying efficacy and side effect profiles. As with any pharmaceutical agent, careful consideration of its pharmacokinetics, potential side effects, and interactions with other medications is essential for safe and effective use.
Formula:C29H32ClNO2
InChI:InChI=1/C29H31NO2/c1-31-26-14-16-28-24(21-26)11-15-27(22-7-3-2-4-8-22)29(28)23-9-12-25(13-10-23)32-20-19-30-17-5-6-18-30/h2-4,7-10,12-14,16,21H,5-6,11,15,17-20H2,1H3
InChI key:InChIKey=HJOOGTROABIIIU-UHFFFAOYSA-N
SMILES:O(C)C=1C=C2C(C(=C(CC2)C3=CC=CC=C3)C4=CC=C(OCCN5CCCC5)C=C4)=CC1.Cl
Synonyms:
  • 1-(2-(p-(3,4-Dihydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy)ethyl)pyrrolidine hydrochloride
  • 1-(2-(p-(6-Methoxy-2-phenyl-3,4-dihydro-1-naphthyl)phenoxy)ethyl)pyrrolidine hydrochloride
  • 1-{2-[4-(6-Methoxy-2-Phenyl-3,4-Dihydronaphthalen-1-Yl)Phenoxy]Ethyl}Pyrrolidine
  • 11100A
  • Ccris 3620
  • NSC 70735
  • Nafoxidine HCl
  • Nafoxidine hydrochloride [USAN:INN]
  • Pyrrolidine 1-(2-(4-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy)ethyl)-, hydrochloride
  • Pyrrolidine, 1-(2-(p-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy)ethyl)-, hydrochloride
  • See more synonyms
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