CAS 1847-63-8

nafoxidine hydrochloride

Description:

Nafoxidine hydrochloride is a synthetic compound primarily recognized for its use as an antiestrogen in the treatment of hormone-dependent cancers, particularly breast cancer. It functions as a selective estrogen receptor modulator (SERM), influencing estrogen activity in various tissues. The substance appears as a white to off-white crystalline powder and is soluble in water and alcohol, which facilitates its administration in pharmaceutical formulations. Nafoxidine hydrochloride has a molecular formula that reflects its complex structure, which includes a phenolic moiety and a piperidine ring, contributing to its biological activity. The compound's mechanism of action involves binding to estrogen receptors, thereby inhibiting estrogen's proliferative effects on target tissues. While it has shown promise in clinical settings, its use has been overshadowed by other SERMs due to varying efficacy and side effect profiles. As with any pharmaceutical agent, careful consideration of its pharmacokinetics, potential side effects, and interactions with other medications is essential for safe and effective use.

Formula: C₂₉H₃₂ClNO₂

InChI: InChI=1/C29H31NO2/c1-31-26-14-16-28-24(21-26)11-15-27(22-7-3-2-4-8-22)29(28)23-9-12-25(13-10-23)32-20-19-30-17-5-6-18-30/h2-4,7-10,12-14,16,21H,5-6,11,15,17-20H2,1H3

InChI key: InChIKey=HJOOGTROABIIIU-UHFFFAOYSA-N

SMILES: O(C)C=1C=C2C(C(=C(CC2)C3=CC=CC=C3)C4=CC=C(OCCN5CCCC5)C=C4)=CC1.Cl

Synonyms:

• 1-(2-(p-(3,4-Dihydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy)ethyl)pyrrolidine hydrochloride
• 1-(2-(p-(6-Methoxy-2-phenyl-3,4-dihydro-1-naphthyl)phenoxy)ethyl)pyrrolidine hydrochloride
• 1-{2-[4-(6-Methoxy-2-Phenyl-3,4-Dihydronaphthalen-1-Yl)Phenoxy]Ethyl}Pyrrolidine
• 11100A
• Ccris 3620
• NSC 70735
• Nafoxidine HCl
• Nafoxidine hydrochloride [USAN:INN]
• Pyrrolidine 1-(2-(4-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy)ethyl)-, hydrochloride
• Pyrrolidine, 1-(2-(p-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy)ethyl)-, hydrochloride
• Pyrrolidine, 1-[2-[4-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy]ethyl]-, hydrochloride (1:1)
• U 11100
• U 11100A
• Unii-Su8Wbd61G1
• Nafoxidine hydrochloride
• Nafoxidene hydrochloride
• Nafoxiden
• 1-[2-[4-(3,4-dihydro-6-Methoxy-2-phenyl-1-naphthalenyl)phenoxy]ethyl]pyrrolidine Hydrochloride
• CP-5600
• 1-(2-(4-(6-Methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy)ethyl)pyrrolidine hydrochloride
• CP-56
• Nafoxidine HCl（1845-11-0 Free base）

Nafoxidine hydrochloride

CAS: 1847-63-8

Formula: C₂₉H₃₂ClNO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 462.0229

Ref: IN-DA003SPH

1-(2-(4-(6-Methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy)ethyl)pyrrolidine hydrochloride

CAS: 1847-63-8

1-(2-(4-(6-Methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy)ethyl)pyrrolidine hydrochloride

Purity: 98%

Molecular weight: 462.03g/mol

Ref: 54-OR1063328

Nafoxidine hydrochloride

CAS: 1847-63-8

Formula: C₂₉H₃₁NO₂·HCl

Purity: ≥ 98.0%

Color and Shape: White to dark yellow or tan powder

Molecular weight: 462.02

Ref: 7W-GP3090

Nafoxidine HCl(1845-11-0 Free base)

CAS: 1847-63-8

Nafoxidine is a partial estrogen antagonist.

Formula: C₂₉H₃₂ClNO₂

Color and Shape: Solid

Molecular weight: 462.03

Ref: TM-T21387

Nafoxidine Hydrochloride

Controlled Product

CAS: 1847-63-8

Applications Nafoxidine is a non-steroidal antiestrogenic drug that is structurally related to Tamoxifen (T006000). Nafoxidine is a potent estrogen receptor antagonist that exhibits anti-proliferative properties.
References Rich, R.L. et al.: Proc. Natl. Acad. Sci. USA, 99, 8562 (2002); Maertens, C. et al.: Br. J. Pharmacol., 132, 135 (2001);

Formula: C₂₉H₃₁NO₂·ClH

Color and Shape: Neat

Molecular weight: 462.02

Ref: TR-N212800