CAS 184866-29-3

(S)-Lercanidipine Hydrochloride

Description:

(S)-Lercanidipine Hydrochloride is a calcium channel blocker primarily used in the treatment of hypertension. It belongs to the dihydropyridine class of compounds, which are characterized by their ability to selectively inhibit calcium influx through L-type calcium channels in vascular smooth muscle and cardiac tissue. This action leads to vasodilation and a subsequent reduction in blood pressure. The substance is a chiral molecule, with the (S)-enantiomer being the active form that exhibits greater pharmacological activity. Lercanidipine is known for its long half-life, allowing for once-daily dosing, which enhances patient compliance. In addition to its antihypertensive effects, it may also have beneficial effects on endothelial function. The hydrochloride salt form enhances its solubility and stability, making it suitable for pharmaceutical formulations. Common side effects may include peripheral edema, headache, and flushing, though it is generally well-tolerated. As with any medication, it is important to consider contraindications and potential drug interactions when prescribing Lercanidipine.

Formula: C₃₆H₄₂ClN₃O₆

InChI: InChI=1/C36H41N3O6.ClH/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27;/h7-19,22,30,33,37H,20-21,23H2,1-6H3;1H/t33-;/m0./s1

SMILES: CC1=C([C@H](c2cccc(c2)N(=O)=O)C(=C(C)N1)C(=O)OC(C)(C)CN(C)CCC(c1ccccc1)c1ccccc1)C(=O)OC.Cl

Synonyms:

• (4S)-1,4-Dihydro-2,6-dimethyl-4-(3-nittrophenyl)-3,5-pyridinedicarboxylic Acid 2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl Methyl Ester Hydrochloride
• 2-[(3,3-diphenylpropyl)(methyl)amino]-1,1-dimethylethyl methyl (4S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride

(S)-Lercanidipine-13C-d3 HCl

CAS: 184866-29-3

Formula: C₃₅₁₃CH₃₈D₃N₃O₆·HCl

Color and Shape: Yellow Solid

Molecular weight: 615.75 36.46

Ref: 4Z-L-1725

(S)-Lercanidipine HCl

CAS: 184866-29-3

Formula: C₃₆H₄₁N₃O₆·HCl

Color and Shape: Yellow Solid

Molecular weight: 611.74 36.46

Ref: 4Z-L-173

(S)-Lercanidipine

CAS: 184866-29-3

Formula: C₃₆H₄₁N₃O₆HCl

Molecular weight: 611.7 : 36.46

Ref: ST-EA-CP-L36028

(S)-Lercanidipine Hydrochloride

Controlled Product

CAS: 184866-29-3

Formula: C₃₆H₄₁N₃O₆·ClH

Color and Shape: Neat

Molecular weight: 648.19

Ref: TR-L179020

(S)-Lercanidipine hydrochloride

CAS: 184866-29-3

(S)-Lercanidipine hydrochloride is the S-enantiomer of Lercanidipine hydrochloride. (S)-lercanidipine hydrochloride is a potent blocker of calcium channel.

Formula: C₃₆H₄₂ClN₃O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 648.19

Ref: TM-T12804