CAS 1850276-58-2

IRAK4-IN-4

CAS: 1850276-58-2

IRAK4-IN-4 (compound 15) inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4)

Formula: C₂₂H₁₆N₂O₂

Purity: 99.52%

Color and Shape: Solid

Molecular weight: 340.37

Ref: TM-T11673

1-(7-Methyl-2-phenylimidazo[1,2-a]pyridin-3-yl)-2-phenylethane-1,2-dione

CAS: 1850276-58-2

Formula: C₂₂H₁₆N₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 340.3746

Ref: IN-DA01KKAV

IRAK4-IN-4

CAS: 1850276-58-2

IRAK4-IN-4

Purity: ≥98%

Molecular weight: 340.37g/mol

Ref: 54-BUP09231

IRAK4-IN-4

CAS: 1850276-58-2

Purity: 99%

Molecular weight: 340.121

Ref: 10-F864390

IRAK4-IN-4

CAS: 1850276-58-2

IRAK4-IN-4 is a research tool for the study of IRAK4. It is an inhibitor that blocks the activity of IRAK4, which is a protein that plays an important role in the activation of NF-κB and MAP kinase pathways. The peptide has been shown to inhibit LPS-induced TNFα production in human monocytes and neutrophils, as well as IL-1β production in mouse macrophages. It has also been shown to inhibit the activation of NF-κB by inhibiting IKKα/β phosphorylation, which usually leads to inhibition of proteasomal degradation of IκBα. This peptide can be used in pharmacological studies as well as cell biology experiments.

Formula: C₂₂H₁₆N₂O₂

Purity: Min. 95%

Molecular weight: 340.4 g/mol

Ref: 3D-AZC27658