CAS 185055-67-8

FERROQUINE

Description:

Ferroquine, with the CAS number 185055-67-8, is a synthetic compound that belongs to the class of 4-aminoquinolines, which are known for their antimalarial properties. It is characterized by its iron-chelating ability, which enhances its efficacy against malaria parasites, particularly in overcoming resistance to traditional antimalarial drugs. Ferroquine exhibits a unique mechanism of action, disrupting the heme detoxification process in the malaria parasite, leading to its death. The compound is typically administered in a pharmaceutical formulation and has been studied for its potential in treating malaria, especially in regions where resistance to other treatments is prevalent. Its chemical structure includes a quinoline ring, which is essential for its biological activity. Additionally, Ferroquine's pharmacokinetics, including absorption, distribution, metabolism, and excretion, are crucial for its therapeutic effectiveness and safety profile. Ongoing research continues to explore its potential applications and optimize its use in malaria treatment regimens.

Formula: C₁₈H₁₉ClN₃·C₅H₅·Fe

InChI: InChI=1S/C18H19ClN3.C5H5.Fe/c1-22(2)12-14-5-3-4-13(14)11-21-17-8-9-20-18-10-15(19)6-7-16(17)18;1-2-4-5-3-1;/h3-10H,11-12H2,1-2H3,(H,20,21);1-5H;/q2*-1;+2

InChI key: InChIKey=DDENDDKMBDTHAX-UHFFFAOYSA-N

SMILES: C(NC=1C2=C(C=C(Cl)C=C2)N=CC1)[C-]34[Fe+2]56789%10%11(C3(CN(C)C)=[CH]5[CH]6=[CH]74)[CH-]%12[CH]8=[CH]9[CH]%10=[CH]%11%12

Synonyms:

• 1-[[(7-Chloro-4-quinolinyl)amino]methyl]-2-[(dimethylamino)methyl]ferrocene
• 7-Chloro-4-(((2-((dimethylamino)methyl)ferrocenyl)methyl)amino)quinoline
• Ferrocene, 1-[[(7-chloro-4-quinolinyl)amino]methyl]-2-[(dimethylamino)methyl]-
• Ferrochloroquine
• Ferroquine [INN]
• Ssr 97193
• Ferroquine
• Ferroquine

1-[[(7-Chloro-4-quinolinyl)amino]methyl]-2-[(dimethylamino)methyl]ferrocene

CAS: 185055-67-8

Formula: C₂₃H₂₄ClFeN₃

Purity: 97%

Molecular weight: 433.7548

Ref: IN-DA00AMBO

Ferroquine

CAS: 185055-67-8

Ferroquine

Purity: ≥98%

Molecular weight: 433.76g/mol

Ref: 54-BUP10334

Ferroquine

Controlled Product

CAS: 185055-67-8

Formula: C₂₃H₂₄ClFeN₃

Color and Shape: Neat

Molecular weight: 433.755

Ref: TR-F307600

Ferroquine

CAS: 185055-67-8

Ferroquine, a ferrocenyl variant of Chloroquine, exhibits antimalarial properties through oxidative stress induction, destroying Plasmodium membranes.

Formula: C₂₃H₂₄ClFeN₃

Purity: 99.97%

Color and Shape: Solid

Molecular weight: 433.76

Ref: TM-T15276

Ferroquine

CAS: 185055-67-8

Ferroquine is a drug that has been shown to be effective in the treatment of cancers and viral infections. It is a ferrous (Fe2+) complex with a quinoline ring. Ferroquine can be synthesized by reacting ferric chloride and quinoline. The Fe2+ ion in the complex binds to the N7 nitrogen atom of guanine, which inhibits DNA synthesis. This inhibition prevents viral replication, resulting in cytotoxicity and cell death. Ferroquine also has potent antifungal activity against Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus. Ferroquine has shown no significant adverse effects on cardiac function or blood pressure, but it is not yet clear if this drug will have any long-term adverse effects on the heart or other parts of the body.

Formula: C₂₃H₂₄ClFeN₃

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 433.75 g/mol

Ref: 3D-KHA05567