CAS 1852-36-4

Pregn-4-ene-3,20-dione, 11,17-dihydroxy-21-(sulfooxy)-, sodium salt (1:1), (11β)-

Description:

Pregn-4-ene-3,20-dione, 11,17-dihydroxy-21-(sulfooxy)-, sodium salt (1:1), commonly known as hydrocortisone sodium succinate, is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties. It is characterized by its steroid structure, which includes a four-ring core typical of steroid hormones, with specific hydroxyl (-OH) groups at the 11 and 17 positions and a sulfooxy (-SO3Na) group that enhances its solubility in water. This compound is often used in medical applications to treat conditions such as adrenal insufficiency, allergic reactions, and inflammatory diseases. Its sodium salt form allows for better solubility and bioavailability, making it suitable for intravenous administration. The compound acts by binding to glucocorticoid receptors, modulating gene expression, and influencing various physiological processes, including metabolism and immune response. As with other corticosteroids, its use must be carefully monitored due to potential side effects, including immunosuppression and metabolic alterations.

Formula: C₂₁H₃₀O₈S·Na

InChI: InChI=1S/C21H30O8S.Na/c1-19-7-5-13(22)9-12(19)3-4-14-15-6-8-21(25,17(24)11-29-30(26,27)28)20(15,2)10-16(23)18(14)19;/h9,14-16,18,23,25H,3-8,10-11H2,1-2H3,(H,26,27,28);/t14-,15-,16-,18+,19-,20-,21-;/m0./s1

InChI key: InChIKey=AOLBTAFZJBOGMY-WDCKKOMHSA-N

SMILES: C[C@@]12[C@]([C@]3([C@]([C@@H](O)C1)([C@]4(C)C(CC3)=CC(=O)CC4)[H])[H])(CC[C@@]2(C(COS(=O)(=O)O)=O)O)[H].[Na]

Synonyms:

• Pregn-4-ene-3,20-dione, 11,17-dihydroxy-21-(sulfooxy)-, sodium salt (1:1), (11β)-
• Hydrocortisone 21-(sodium sulphate)
• Pregn-4-ene-3,20-dione, 11,17-dihydroxy-21-(sulfooxy)-, monosodium salt, (11β)-
• Cortisol, 21-(hydrogen sulfate), monosodium salt
• sodium (11beta)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl sulfate

Cortisol sulfate sodium

CAS: 1852-36-4

Cortisol sulfate sodium, a Cortisol metabolite, binds specifically to intracellular transcortin.

Formula: C₂₁H₂₉NaO₈S

Color and Shape: Solid

Molecular weight: 464.51

Ref: TM-T75683