CAS 185243-69-0

TNFR-Fc fusion protein

Description:

TNFR-Fc fusion protein, associated with the CAS number 185243-69-0, is a recombinant protein that combines the extracellular domain of the tumor necrosis factor receptor (TNFR) with the Fc region of an immunoglobulin. This fusion protein is designed to inhibit the activity of tumor necrosis factor-alpha (TNF-α), a cytokine involved in systemic inflammation and implicated in various autoimmune diseases. The characteristics of TNFR-Fc include its ability to bind TNF-α with high affinity, effectively neutralizing its pro-inflammatory effects. This protein is typically produced in mammalian cell systems to ensure proper glycosylation and folding. TNFR-Fc is utilized in therapeutic applications, particularly in the treatment of conditions such as rheumatoid arthritis, Crohn's disease, and psoriasis. Its mechanism of action involves sequestering TNF-α, thereby preventing it from interacting with its receptors on target cells. The stability, solubility, and pharmacokinetics of TNFR-Fc are critical for its efficacy as a therapeutic agent, making it an important subject of study in biopharmaceutical development.

Formula: C₄H₆N₄O₁₂

InChI: InChI=1/C4H6N4O12/c9-5(10)17-1-3(19-7(13)14)4(20-8(15)16)2-18-6(11)12/h3-4H,1-2H2/t3-,4+

Synonyms:

• Etanercept [USAN]
• 1-235-Tumor necrosis factor receptor (human) fusion protein with 236-467-immunoglobulin G1 (human gamma1-chain Fc fragment), dimer
• Enbrel
• Etanercept
• Recombinant human TNF
• Recombinant human dimeric TNF receptor type II-IgG fusion protein
• TNF receptor type II-IgG fusion protein
• TNFR-Fc
• Tnr 001
• Unii-Op401G7Ojc
• rhu TNFR:Fc
• 1-235-Tumor necrosis factor receptor (human) fusion protein with 236-467-immunoglobulin G1 (human gamma1-chain Fc fragment)

ETANERCEPT CRS

CAS: 185243-69-0

ETANERCEPT CRS

Ref: 41-Y0001969

ETANERCEPT BRP

CAS: 185243-69-0

ETANERCEPT BRP

Ref: 41-Y0002042

Etanercept (Recombinant TNF Receptor II Fc Fusion Protein) for Bioassays

CAS: 185243-69-0

Immunological products, put up in measured doses or in forms or packings for retail sale

Formula: C₄₄₄₈H₆₉₃₂N₁₂₃₆O₁₄₀₂S₇₂

Color and Shape: White Powder

Molecular weight: 102396.90201

Ref: 45-1255900

Etanercept

CAS: 185243-69-0

Etanercept is a fusion protein consisting of the soluble portion of the p75-tumor necrosis factor receptor (TNFR) and the Fc fragment of human IgG1 and is commonly used to treat patients with rheumatoid arthritis.Cost-effective and quality-assured.

Purity: 98%

Color and Shape: Liquid

Ref: TM-T37445

Etanercept - Buffer solution

CAS: 185243-69-0

Etanercept is a recombinant protein that binds to both the soluble and transmembrane forms of TNF-α. It is used to treat rheumatoid arthritis, psoriasis, Crohn's disease, ankylosing spondylitis, and other inflammatory diseases. Etanercept has been shown to be effective in reducing symptoms of rheumatoid arthritis and decreasing levels of c-reactive protein (CRP). Etanercept binds to TNF-α and prevents it from activating cells. It also reduces production of other pro-inflammatory cytokines such as IL-1 receptor antagonist and necrosis factor.

Purity: Min. 95%

Ref: 3D-FE159605