CAS 185246-32-6

RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE

Description:

RP-8-Bromo-beta-phenyl-1,N2-ethenoguanosine 3',5'-cyclic monophosphorothioate sodium salt hydrate is a synthetic nucleotide analog that is primarily used in biochemical research, particularly in studies involving cyclic nucleotide signaling pathways. This compound features a bromo-substituted phenyl group, which enhances its biological activity and specificity. The presence of the phosphorothioate moiety imparts increased stability against enzymatic degradation compared to its non-thioate counterparts, making it a valuable tool in pharmacological studies. As a sodium salt hydrate, it is typically soluble in aqueous solutions, facilitating its use in various experimental setups. The compound is often employed to investigate the roles of cyclic GMP and cyclic AMP in cellular signaling, as well as in the development of potential therapeutic agents targeting these pathways. Its unique structural characteristics allow for selective interactions with specific receptors or enzymes, contributing to its utility in molecular biology and pharmacology research.

Formula: C₁₈H₁₄N₅O₆PSBrNa

Synonyms:

• Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3μ:5μ-cyclic monophosphorothioate hydrate sodium salt
• Rp-8-Br-PET-cGMPS hydrate, Rp-β-Phenyl-1,N2-etheno-8-bromoguanosine 3μ,5μ-cyclic monophosphorothioate hydrate sodium salt

Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate sodium salt

CAS: 185246-32-6

Formula: C₁₈H₁₄BrN₅NaO₆PS

Molecular weight: 562.27

Ref: 7W-GK5802

Rp-8-Br-PET-cGMPS

CAS: 185246-32-6

cGMP-dependent protein kinase (PKG) inhibitor

Formula: C₁₈H₁₅BrN₅NaO₆PS

Purity: 98%

Color and Shape: Solid

Molecular weight: 563.27

Ref: TM-T23252

Rp-8-Br-PET-cGMPS

CAS: 185246-32-6

Rp-8-Br-PET-cGMPS is a cytosolic calcium analog that inhibits the production of cyclic GMP and has been shown to be an effective anticancer agent. It binds to the camp receptor, which is found in high concentrations in cancer cells, and blocks the uptake of cAMP by inhibiting the adenosine 3 receptor. Rp-8-Br-PET-cGMPS also inhibits the activity of mt2 receptors, which are responsible for the release of Ca2+ from intracellular stores into the cytoplasm. This inhibition limits Ca2+ uptake by the mitochondria and decreases ATP production, leading to cell death. The 8-Br group confers solubility in organic solvents, making this compound more amenable to drug development.

Formula: C₁₈H₁₄BrN₅NaO₆PS

Purity: Min. 95%

Molecular weight: 562.27 g/mol

Ref: 3D-KHA24632