CAS 185461-45-4

(SAR1,ILE4,8)-ANGIOTENSIN II

Description:

(SAR1,ILE4,8)-Angiotensin II is a synthetic analog of the naturally occurring peptide hormone angiotensin II, which plays a crucial role in regulating blood pressure and fluid balance. This compound is characterized by specific amino acid substitutions that enhance its stability and biological activity compared to the native form. The modifications typically involve the substitution of certain residues to improve receptor binding affinity and resistance to enzymatic degradation. As a result, (SAR1,ILE4,8)-Angiotensin II exhibits potent vasoconstrictive properties and can influence cardiovascular functions. It is often used in research to study the renin-angiotensin system and its implications in various physiological and pathological conditions, including hypertension and heart failure. The compound's pharmacological profile makes it a valuable tool in both experimental and clinical settings, allowing for a better understanding of angiotensin II's role in human health. Additionally, its synthetic nature allows for controlled studies on its effects and potential therapeutic applications.

Formula: C₄₃H₇₅N₁₃O₉

Synonyms:

• Sar-Arg-Val-Ile-Ile-His-Pro-Ile-Oh

(Sar¹,Ile⁴·⁸)-Angiotensin II

CAS: 185461-45-4

SII-Angiotensin II activates extracellular signal-regulated kinases 1 and 2 (ERK1/2) via angiotensin II type 1A receptors. Activation is dependent on β-arrestin 2 expression.

Formula: C₄₃H₇₅N₁₃O₉

Purity: > 96%

Color and Shape: White Lyophilisate

Molecular weight: 918.15

Ref: 01-4048101

Sar1, Ile4,8]-Angiotensin II

CAS: 185461-45-4

Sar1, Ile4,8]-Angiotensin II is a peptide that belongs to the class of angiotensins. It has been shown to activate angiotensin receptors and is used as a research tool in pharmacology and cell biology. Sar1, Ile4,8]-Angiotensin II interacts with ligands such as heparin-binding EGF-like growth factor (HB-EGF) and angiopoietin 1 (ANGPT1). The antibody against Sar1, Ile4,8]-Angiotensin II blocks the receptor binding activity of this peptide. Sar1, Ile4,8]-Angiotensin II has been shown to be an inhibitor of ion channels such as inward rectifier potassium channels.

Formula: C₄₃H₇₅N₁₃O₉

Purity: Min. 95%

Molecular weight: 918.14 g/mol

Ref: 3D-PAN-4476-V

(Sar 1,Ile4·8)-Angiotensin II trifluoroacetate salt

CAS: 185461-45-4

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Formula: C₄₃H₇₅N₁₃O₉

Purity: Min. 95%

Molecular weight: 918.14 g/mol

Ref: 3D-FS109771