Azido-PEG3-Maleimide is a chemical compound that belongs to the class of polyethylene glycol (PEG) derivatives, specifically designed for bioconjugation applications. It features an azide functional group, which is highly reactive and can participate in click chemistry, particularly with alkynes, facilitating the formation of stable triazole linkages. The maleimide group in this compound is known for its ability to selectively react with thiol groups, making it useful for conjugating proteins, peptides, or other biomolecules. The PEG3 component provides hydrophilicity, enhancing solubility in aqueous environments and improving the pharmacokinetic properties of conjugated molecules. This compound is often utilized in the fields of biochemistry and molecular biology for labeling, drug delivery, and the development of targeted therapies. Its stability, reactivity, and biocompatibility make it a valuable tool in the synthesis of complex biomolecular constructs. As with all chemical substances, proper handling and safety precautions should be observed when working with Azido-PEG3-Maleimide.

Azido-PEG3-Maleimide is provided as a kit of two vials. Azido-PEG3-Maleimide is not stable for storage; it needs to be made in situ by mixing Azido-PEG3-amine and Maleimide-NHS ester followed by shaking/ stirring for 30 minutes at room temperature. The maleimide group of the Azido-PEG3-Maleimide can react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. Azide group enables Click Chemsitry reactions.

Azido-PEG3-Maleimide

1858264-36-4: Azido-PEG3-Maleimide is a chemical compound that belongs to the class of polyethylene glycol (PEG) derivatives, specifically designed for bioconjugation applications. It features an azide functional group, which is highly reactive and can participate in click chemistry, particularly with alkynes, facilitating the formation of stable triazole linkages. The maleimide group in this compound is known for its ability to selectively react with thiol groups, making it useful for conjugating proteins, peptides, or other biomolecules. The PEG3 component provides hydrophilicity, enhancing solubility in aqueous environments and improving the pharmacokinetic properties of conjugated molecules. This compound is often utilized in the fields of biochemistry and molecular biology for labeling, drug delivery, and the development of targeted therapies. Its stability, reactivity, and biocompatibility make it a valuable tool in the synthesis of complex biomolecular constructs. As with all chemical substances, proper handling and safety precautions should be observed when working with Azido-PEG3-Maleimide.

<p>Azido-PEG3-maleimide: a PEG linker for PROTACs and cleavable PEG ADC synthesis.</p>

CAS 1858264-36-4

Azido-PEG3-Maleimide

Azido-PEG3-maleimide

Ref: TM-T14429