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CAS 185954-98-7

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Eritoran tetrasodium

Description:
Eritoran tetrasodium, also known as E556, is a synthetic compound that acts as a lipid A antagonist, primarily studied for its potential use in treating sepsis and other inflammatory conditions. It is a tetrasodium salt of a synthetic derivative of lipid A, which is a component of lipopolysaccharides found in the outer membrane of Gram-negative bacteria. The compound is characterized by its ability to inhibit the activation of Toll-like receptor 4 (TLR4), thereby modulating the immune response and reducing inflammation. Eritoran tetrasodium is typically soluble in water, which facilitates its administration in clinical settings. Its pharmacological profile includes anti-inflammatory properties, making it a candidate for therapeutic applications in conditions associated with excessive immune responses. However, its clinical use has been limited, and ongoing research continues to explore its efficacy and safety in various medical contexts. As with any pharmaceutical agent, understanding its mechanism of action, potential side effects, and interactions with other medications is crucial for its application in healthcare.
Formula:C66H126N2O19P2·4Na
InChI:InChI=1S/C66H126N2O19P2.4Na/c1-7-11-15-19-22-25-26-27-28-29-30-32-34-38-42-46-57(70)67-60-64(82-49-47-54(80-6)45-41-36-18-14-10-4)62(86-88(73,74)75)56(51-79-5)85-65(60)83-52-55-61(72)63(81-48-43-39-35-24-21-17-13-9-3)59(66(84-55)87-89(76,77)78)68-58(71)50-53(69)44-40-37-33-31-23-20-16-12-8-2;;;;/h25-26,54-56,59-66,72H,7-24,27-52H2,1-6H3,(H,67,70)(H,68,71)(H2,73,74,75)(H2,76,77,78);;;;/b26-25-;;;;/t54-,55-,56-,59-,60-,61-,62-,63-,64-,65-,66-;;;;/m1..../s1
InChI key:InChIKey=QGRQWYPRJPEHDL-RHMAUSBNSA-N
SMILES:O(CC[C@@H](CCCCCCC)OC)[C@@H]1[C@@H](NC(CCCCCCCCC/C=C\CCCCCC)=O)[C@H](OC[C@@H]2[C@@H](O)[C@H](OCCCCCCCCCC)[C@@H](NC(CC(CCCCCCCCCCC)=O)=O)[C@@H](OP(=O)(O)O)O2)O[C@H](COC)[C@H]1OP(=O)(O)O.[Na]
Synonyms:
  • B 1287
  • Eritorantetrasodium
  • α-D-Glucopyranose, 3-O-decyl-2-deoxy-6-O-[2-deoxy-3-O-[(3R)-3-methoxydecyl]-6-O-methyl-2-[[(11Z)-1-oxo-11-octadecenyl]amino]-4-O-phosphono-β-D-glucopyranosyl]-2-[(1,3-dioxotetradecyl)amino]-, 1-(dihydrogen phosphate), tetrasodium salt
  • Eritoran tetrasodium
  • a-D-Glucopyranose,3-O-decyl-2-deoxy-6-O-[2-deoxy-3-O-[(3R)-3-methoxydecyl]-6-O-methyl-2-[[(11Z)-1-oxo-11-octadecenyl]amino]-4-O-phosphono-b-D-glucopyranosyl]-2-[(1,3-dioxotetradecyl)amino]-,1-(dihydrogen phosphate), tetrasodium salt (9CI)
  • B 1287
  • E 5564
  • E 5564
  • α-D-Glucopyranose, 3-O-decyl-2-deoxy-6-O-[2-deoxy-3-O-[(3R)-3-methoxydecyl]-6-O-methyl-2-[[(11Z)-1-oxo-11-octadecen-1-yl]amino]-4-O-phosphono-β-D-glucopyranosyl]-2-[(1,3-dioxotetradecyl)amino]-, 1-(dihydrogen phosphate), sodium salt (1:4)
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