CAS 185991-07-5

2-Pyridinemethanamine, N-[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-, hydrobromide (1:6)

Description:

2-Pyridinemethanamine, N-[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-, hydrobromide (1:6) is a complex organic compound characterized by its unique structure, which includes a pyridine ring and a tetraazacyclotetradecane moiety. This compound features a hydrobromide salt form, indicating it is protonated and exists as a bromide salt, which can enhance its solubility in polar solvents. The presence of multiple nitrogen atoms in the tetraazacyclotetradecane structure suggests potential chelating properties, making it of interest in coordination chemistry and possibly in medicinal chemistry for drug development. The compound's molecular structure may impart specific biological activities, potentially influencing its interactions with biological targets. Additionally, the hydrobromide form can affect the compound's stability and reactivity. Overall, this substance is notable for its complex architecture and potential applications in various fields, including pharmaceuticals and materials science.

Formula: C₂₄H₃₈N₆

InChI: InChI=1/C24H38N6/c1-2-13-29-24(5-1)20-28-19-22-6-8-23(9-7-22)21-30-17-4-12-26-15-14-25-10-3-11-27-16-18-30/h1-2,5-9,13,25-28H,3-4,10-12,14-21H2

InChI key: InChIKey=ARHBIBDGWDRBJH-UHFFFAOYSA-N

SMILES: C(C1=CC=C(CNCC2=CC=CC=N2)C=C1)N3CCCNCCNCCCNCC3.Br

Synonyms:

• 2-Pyridinemethanamine, N-((3-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl)methyl)-
• 2-Pyridinemethanamine, N-[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-, hexahydrobromide
• 2-Pyridinemethanamine, N-[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-, hydrobromide (1:6)
• Amd 3465
• Genz 644494
• AMD3465,98%
• AMD3465;AMD-3465;AMD 3465
• 1-(2-Pyridinyl)-N-[4-(1,4,8,11-tetraazacyclotetradecan-1-ylMethyl)benzyl]MethanaMine
• AMD 3465 (hydrobroMide)
• AMD 3465 (*Hexahydrobromide*)
• N-[[4-(1,4,8,11-Tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine hexahydrobromide
• CS-810
• AMD3465 R10406hexahydrobromide

N-[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-Pyridinemethanamine hexahydrobromide

CAS: 185991-07-5

Formula: C₂₄H₄₄Br₆N₆

Purity: 97%

Color and Shape: Solid

Molecular weight: 896.0704

Ref: IN-DA003NTV

AMD 3465 hexahydrobromide

CAS: 185991-07-5

AMD 3465 hexahydrobromide

Purity: ≥98%

Molecular weight: 896.07g/mol

Ref: 54-BUP10442

AMD 3465 hexahydrobromide

CAS: 185991-07-5

AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity.

Formula: C₂₄H₄₄Br₆N₆

Purity: 99.39%

Color and Shape: Solid

Molecular weight: 896.07

Ref: TM-T7208

AMD 3465

CAS: 185991-07-5

AMD 3465 is a potent CXCR4 antagonist, which is derived from small-molecule chemical synthesis. This compound functions by specifically targeting and binding to the CXC chemokine receptor 4 (CXCR4), thereby hindering the interaction between the receptor and its natural ligand, stromal-derived factor-1 (SDF-1 or CXCL12). By blocking this interaction, AMD 3465 effectively disrupts signaling pathways involved in cellular processes such as chemotaxis, proliferation, and survival.

Formula: C₂₄H₃₈N₆•(HBr)₆

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 896.07 g/mol

Ref: 3D-KHA99107

AMD 3465

Controlled Product

CAS: 185991-07-5

Applications AMD 3465 is a CXCR4 antagonist and in combination with monoclonal antibody, was shown to be potentially effective in reducing tumor growth and increasing survival in patient with B cell lymphoma
References Burger, J.A., et al.: Leuke. Lympho.,53. 3 (2012); Lam, A.R., et al.: J. Chem. Info. Model., 51, 139 (2011); De Clercq. E., et al.: Pharmacol. Therap., 128. 509 (2010);

Formula: C₂₄H₃₈N₆·6BrH

Color and Shape: Neat

Molecular weight: 896.07

Ref: TR-A576350