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CAS 186040-50-6

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Protaxel

Description:
Protaxel, with the CAS number 186040-50-6, is a semi-synthetic derivative of paclitaxel, a well-known chemotherapeutic agent used primarily in the treatment of various cancers, including ovarian and breast cancer. Protaxel is designed to enhance the therapeutic efficacy of paclitaxel while potentially reducing its side effects. It exhibits characteristics typical of taxanes, such as the ability to inhibit microtubule depolymerization, thereby disrupting normal cell division and leading to apoptosis in cancer cells. The compound is often characterized by its complex molecular structure, which includes a taxane core with specific modifications that improve its pharmacokinetic properties. Protaxel is generally administered intravenously and is subject to ongoing research to evaluate its effectiveness and safety profile in clinical settings. As with many chemotherapeutic agents, its use may be accompanied by side effects, necessitating careful monitoring during treatment. Overall, Protaxel represents an important advancement in cancer therapy, aiming to provide more effective treatment options for patients.
Formula:C51H57NO18
InChI:InChI=1S/C51H57NO18/c1-27-34(67-46(61)39(57)38(30-16-10-7-11-17-30)52-44(59)31-18-12-8-13-19-31)23-51(63)43(69-45(60)32-20-14-9-15-21-32)41-49(6,42(58)40(66-28(2)54)37(27)48(51,4)5)35(68-47(62)64-25-33(56)24-53)22-36-50(41,26-65-36)70-29(3)55/h7-21,33-36,38-41,43,53,56-57,63H,22-26H2,1-6H3,(H,52,59)/t33?,34-,35-,36+,38-,39+,40+,41-,43-,49+,50-,51+/m0/s1
InChI key:InChIKey=HSUDWURBWSUCOB-JPHWUADUSA-N
SMILES:O(C(C)=O)[C@]12[C@@]3([C@@](C)([C@@H](OC(OCC(CO)O)=O)C[C@]1(OC2)[H])C(=O)[C@H](OC(C)=O)C=4C(C)(C)[C@](O)([C@H]3OC(=O)C5=CC=CC=C5)C[C@H](OC([C@@H]([C@@H](NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)O)=O)C4C)[H]
Synonyms:
  • Protaxel
  • Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-4-[[(2,3-dihydroxypropoxy)carbonyl]oxy]-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
  • Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-4-[[(2,3-dihydroxypropoxy)carbonyl]oxy]-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
  • Paclitaxel ceribate
  • BP 179
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