CAS 1860875-51-9

Eragidomide

CAS: 1860875-51-9

Eragidomide (Cereblon modulator 1) is a CRBN E3 ligase modulator, specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex.

Formula: C₂₂H₁₈ClF₂N₃O₄

Purity: 97.51% - 99.63%

Color and Shape: Solid

Molecular weight: 461.85

Ref: TM-T10765

2-(4-Chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide

CAS: 1860875-51-9

Formula: C₂₂H₁₈ClF₂N₃O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 461.8458

Ref: IN-DA01KW1E

Eragidomide

CAS: 1860875-51-9

Eragidomide

Purity: ≥95%

Molecular weight: 461.85g/mol

Ref: 54-BUP02425

Eragidomide

CAS: 1860875-51-9

Molecular weight: 461.85

Ref: 10-F987046

Cereblon modulator 1

CAS: 1860875-51-9

Cereblon modulator 1 is a prodrug that binds to the E3 ubiquitin ligase, Cereblon, and blocks its activity. This drug is being studied for use in hematologic malignancies. Cereblon modulator 1 has been shown to inhibit the proliferation of myelodysplastic cells by inducing c-myc protein degradation and inhibiting IL-1 receptor activation. The drug also inhibits the growth of cancer cells by blocking the Tautomerase function of Cereblon, thereby preventing the conversion of inactive proteins into active proteins. Cereblon modulator 1's linker is heterocyclic, which is likely responsible for its antagonist effect on IL-1 receptor activation.

Formula: C₂₂H₁₈ClF₂N₃O₄

Purity: Min. 95%

Molecular weight: 461.8 g/mol

Ref: 3D-KZC87551