CAS 186139-09-3: Trodusquemine

Description: Trodusquemine, also known by its chemical name, is a synthetic compound that has garnered interest in the field of biochemistry and pharmacology. It is primarily recognized for its role as a selective inhibitor of protein phosphatase 2A (PP2A), an enzyme that plays a crucial role in various cellular processes, including cell growth and division. The inhibition of PP2A by trodusquemine has potential implications in cancer research, as it may influence tumor growth and proliferation. The compound exhibits a complex molecular structure, which contributes to its biological activity. Trodusquemine has been studied for its effects on metabolic pathways and its potential therapeutic applications, particularly in the context of obesity and metabolic disorders. Additionally, its pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion, are essential for understanding its efficacy and safety profile. Overall, trodusquemine represents a significant area of research in drug development, particularly for conditions related to cellular signaling and metabolic regulation.

Formula: C₃₇H₇₂N₄O₅S

InChI: InChI=1S/C37H72N4O5S/c1-26(2)34(46-47(43,44)45)13-10-27(3)30-11-12-31-35-32(15-17-37(30,31)5)36(4)16-14-29(24-28(36)25-33(35)42)41-23-9-22-40-20-7-6-19-39-21-8-18-38/h26-35,39-42H,6-25,38H2,1-5H3,(H,43,44,45)/t27-,28-,29+,30-,31+,32+,33-,34-,35+,36+,37-/m1/s1

InChI key: InChIKey=WUJVPODXELZABP-FWJXURDUSA-N

SMILES: O=S(=O)(O)OC(CCC(C)C1CCC2C3C(O)CC4CC(NCCCNCCCCNCCCN)CCC4(C)C3CCC12C)C(C)C

Synonyms:

• Cholestane-7,24-diol, 3-[[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]amino]-, 24-(hydrogen sulfate), (3β,5α,7α,24R)-
• Aminosterol 1436
• MSI 1436
• Trodusquemine

MSI-1436

CAS: 186139-09-3

• Formula: C₃₇H₇₂N₄O₅S
• Molecular weight: 685.0564

Trodusquemine

CAS: 186139-09-3

• Formula: C₃₇H₇₂N₄O₅S
• Color and Shape: Off-White
• Molecular weight: 685.056

Trodusquemine

CAS: 186139-09-3

Inhibitor of protein tyrosine phosphatase PTP1B

• Formula: C₃₇H₇₂N₄O₅S
• Purity: Min. 95%
• Molecular weight: 685.06 g/mol

MSI-1436

CAS: 186139-09-3

MSI-1436 is a selective, non-competitive the enzyme protein-tyrosine phosphatase 1B (PTB1B)inhibitor(IC50 of appr 1 μM)

• Formula: C₃₇H₇₂N₄O₅S
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 685.06