CAS 186142-28-9

(Asn670,Leu671)-Amyloid Beta/A4 Protein Precursor770 (667-676)

Description:

The chemical substance known as "(Asn670,Leu671)-Amyloid Beta/A4 Protein Precursor770 (667-676)" with the CAS number 186142-28-9 is a peptide fragment derived from the amyloid precursor protein (APP), specifically associated with Alzheimer's disease pathology. This peptide consists of a sequence of amino acids that includes asparagine (Asn) at position 670 and leucine (Leu) at position 671, which are critical for its biological activity and aggregation properties. The amyloid beta peptide is known for its role in the formation of amyloid plaques, a hallmark of Alzheimer's disease. The characteristics of this peptide include its hydrophobic nature, which facilitates aggregation, and its ability to interact with various cellular components, potentially leading to neurotoxicity. Additionally, the peptide's structure can influence its propensity to form fibrils, impacting its biological function and the progression of neurodegenerative processes. Understanding the properties of this peptide is crucial for developing therapeutic strategies aimed at mitigating Alzheimer's disease.

Formula: C₅₀H₇₈N₁₄O₁₉

Synonyms:

• Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg
• Sevnldaefr
• A4 Protein Precursor770 (667-676)
• (Asn670,Leu671)-App770 (667-676)
• [Asn670, Leu671]Amyloid-Beta
• Beta-Secretase Substrate Ii
• H-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Oh
• (Asn670,Leu671)-Amyloid Beta/A4 Protein Precursor770 (667-676)
• (Asn???,Leu??1)-Amyloid β/A4 Protein Precursor??? (667-676) trifluoroacetate salt
• (Asn???,Leu???)-Amyloid β/A4 Protein Precursor??? (667-676) trifluoroacetate salt
• Asn670, Leu671]-Amyloid beta/A4 Precursor Protein 770 Fragment 667-676 trifluoroacetate salt
• (ASN670,LEU671)-AMYLOID BETA/A4 PROTEIN PRECURSOR 7
• (Asn670,Leu671)-APP770 (667-676), APP770 (667-676) Swedish Mutation
• [asn670, leu671]-amyloid β/a4 precursor protein 770 fragment 667-676 trifluoroacetate salt
• (Asn,Leu61)-Amyloid β/A4 Protein Precursor (667-676)
• (ASN670,LEU671)-AMYLOID BETA/A4 PROTEIN PRECURSOR770 (667-676) USP/EP/BP
• L-Arginine, L-seryl-L-α-glutamyl-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-
• (Asn670,Leu671)-Amyloid b/A4 Protein Precursor770 (667-676) trifluoroacetate salt
• H-Ser-Glu-Val-Asn
• [Asn670,Leu671]-Amyloid β/A4 Protein Precursor770 (667-676)
• Asn670, Leu671]-Amyloid beta/A4 Precursor Protein 770 Fragment 667-676 trifluoroacetate salt >=95% (HPLC), solid
• (Asn???,Leu6?1)-Amyloid β/A4 Protein Precursor??? (667-676)

(Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (667-676)

CAS: 186142-28-9

This peptide substrate corresponds to the ‘Swedish’ Lys-Met/Asn-Leu (K670N/M671L) mutation of the amyloid precursor protein (APP) β-secretase cleavage site. It has been used for assaying β-secretase activity.

Formula: C₅₀H₇₈N₁₄O₁₉

Purity: 95.4%

Color and Shape: White Powder

Molecular weight: 1179.25

Ref: 01-4029475

(Asn670,Leu671)-Amyloid b/A4 Protein Precursor770 (667-676) trifluoroacetate salt

CAS: 186142-28-9

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Formula: C₅₀H₇₈N₁₄O₁₉

Purity: Min. 95%

Molecular weight: 1,179.24 g/mol

Ref: 3D-FA109374