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CAS 1862226-99-0

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  • Clifutinib
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    Clifutinib

    CAS:
    <p>Clifutinib (Compound 9e) is an orally active, selective inhibitor of FMS-like tyrosine kinase 3 (FLT3-ITD) with an IC50 of 15.1 nM. It inhibits FLT3-ITD kinase activity and blocks downstream signaling pathways, including RAS/MAPK, PI3K/AKT, and JAK/STAT5. Clifutinib induces apoptosis in FLT3-ITD mutated acute myeloid leukemia (AML) cells and is a potential candidate for research in relapsed/refractory FLT3-ITD positive AML.</p>
    Formula:C29H34N4O4
    Color and Shape:Solid
    Molecular weight:502.605

    Ref: TM-T206767