CymitQuimica logo

CAS 186353-53-7

:

amrubicinol

Description:
Amrubicinol, with the CAS number 186353-53-7, is a derivative of amrubicin, which is an anthracycline antibiotic used primarily in cancer therapy. This compound exhibits potent antitumor activity, primarily through its mechanism of intercalating into DNA, thereby inhibiting topoisomerase II and disrupting DNA replication and transcription. Amrubicinol is characterized by its ability to induce apoptosis in cancer cells, making it a valuable agent in the treatment of various malignancies, particularly in cases of resistant tumors. The substance is typically administered intravenously and has a specific pharmacokinetic profile, including metabolism primarily in the liver. Its side effects may include myelosuppression, cardiotoxicity, and gastrointestinal disturbances, which are common among anthracycline derivatives. Research continues to explore its efficacy and safety profile, as well as potential combinations with other therapeutic agents to enhance its anticancer effects while minimizing adverse reactions. Overall, amrubicinol represents a significant compound in the field of oncology, contributing to the arsenal of chemotherapeutic agents available for cancer treatment.
Formula:C25H27NO9
InChI:InChI=1/C25H27NO9/c1-10(27)25(26)7-13-18(16(8-25)35-17-6-14(28)15(29)9-34-17)24(33)20-19(23(13)32)21(30)11-4-2-3-5-12(11)22(20)31/h2-5,10,14-17,27-29,32-33H,6-9,26H2,1H3/t10?,14-,15-,16?,17+,25+/m1/s1
Synonyms:
  • (7S,9S)-9-Amino-7-[(2-deoxy--D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxy-9-(1-hydroxyethyl)-5,12-naphthacenedione
  • 13-Hydroxy SM 5887
Sort by
The purity filter is not visible because current products do not have associated purity data for filtering.
Found 3 products.