CAS 1863916-88-4

Dolutegravir Impurity 4

CAS: 1863916-88-4

Formula: C₂₀H₂₀FN₃O₅

Color and Shape: White To Off-White Solid

Molecular weight: 401.39

Ref: 4Z-D-093006

Dolutegravir Impurity G

CAS: 1863916-88-4

Formula: C₂₀H₂₀FN₃O₅

Molecular weight: 401.39

Ref: ST-EA-CP-D24007

Defluoro Dolutegravir (>85%)

CAS: 1863916-88-4

Applications Defluoro Dolutegravir is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
References Kobayashi, M. et al. Antimicrob Agents Chemother., 55, 813 (2011); Garrido, C. et al.: Antiviral, Res., 90, 164 (2011); Lenz, J.C.C. et al.: Exp. Opin. Invest. Drugs, 20, 537 (2011);

Formula: C₂₀H₂₀FN₃O₅

Purity: >85%

Color and Shape: Neat

Molecular weight: 401.39

Ref: TR-D228715

Defluoro dolutegravir

CAS: 1863916-88-4

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Formula: C₂₀H₂₀FN₃O₅

Purity: Min. 95%

Molecular weight: 401.4 g/mol

Ref: 3D-NZC91688