CAS 186407-74-9

4-Bromo (1H)Indazole

Description:

4-Bromo(1H)indazole is a heterocyclic organic compound characterized by its indazole core, which consists of a fused benzene and pyrazole ring structure. The presence of a bromine atom at the 4-position of the indazole ring significantly influences its chemical properties, including reactivity and solubility. This compound is typically a solid at room temperature and exhibits moderate stability under standard conditions. It is known for its potential applications in medicinal chemistry, particularly in the development of pharmaceuticals, due to its ability to interact with biological targets. The bromine substituent can enhance the compound's lipophilicity, affecting its bioavailability and pharmacokinetics. Additionally, 4-bromo(1H)indazole can participate in various chemical reactions, such as nucleophilic substitutions and coupling reactions, making it a valuable intermediate in organic synthesis. Safety data should be consulted for handling and storage, as halogenated compounds can pose health risks. Overall, 4-bromo(1H)indazole is a versatile compound with significant implications in chemical research and drug development.

Formula: C₇H₅BrN₂

InChI: InChI=1/C7H5BrN2/c8-6-2-1-3-7-5(6)4-9-10-7/h1-4H,(H,9,10)

SMILES: c1cc(c2cn[nH]c2c1)Br

Synonyms:

• 4-Bromoindazole
• 4-Bromo(1H)Indazole
• 4-Bromo-1H-Indazole

4-Bromo-1H-indazole, 97+%

CAS: 186407-74-9

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₇H₅BrN₂

Purity: 97+%

Molecular weight: 197.04

Ref: 02-H64527

4-Bromo-1H-indazole

CAS: 186407-74-9

Formula: C₇H₅BrN₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 197.0320

Ref: IN-DA0033YH

4-Bromo-1H-indazole

CAS: 186407-74-9

4-Bromo-1H-indazole

Formula: C₇H₅BrN₂

Purity: ≥95%

Color and Shape: off white to light brown solid

Molecular weight: 197.03g/mol

Ref: 54-OR12759

4-Bromoindazole

CAS: 186407-74-9

Ref: 7W-GK2161

4-Bromoindazole

CAS: 186407-74-9

Formula: C₇H₅BrN₂

Purity: >98.0%(GC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 197.04

Ref: 3B-B4631

4-Bromo-1H-indazole

CAS: 186407-74-9

Purity: 98%

Molecular weight: 197.032

Ref: FT-CAPOB11054

4-Bromo-1H-indazole

CAS: 186407-74-9

Formula: C₇H₅BrN₂

Purity: 95%

Color and Shape: Solid, Yellow powder

Molecular weight: 197.035

Ref: 10-F067565

4-Bromoindazole

CAS: 186407-74-9

4-Bromoindazole is an antibacterial agent that binds to the protonated form of the staphylococcal enzyme methicillin-resistant penicillinase (MRP) and prevents the enzyme from participating in the synthesis of cell wall precursors. The molecular modeling studies of 4-bromoindazole have shown that it can bind to pyogenes, a bacterium that causes streptococcal pharyngitis, by hydrogen bonding between its amide group and pyogenes' carboxylic acid group. 4-Bromoindazole also has anticancer activity against cancer cells with v600e mutation. It has been shown that 4-bromoindazole inhibits cancer cell proliferation by binding to the oxacillin site on DNA gyrase and topoisomerase IV, leading to DNA damage and apoptosis.

Purity: Min. 95%

Ref: 3D-FB29052