CAS 186497-07-4

Zibotentan

Description:

Zibotentan, with the CAS number 186497-07-4, is a small molecule that acts as an endothelin receptor antagonist, specifically targeting the endothelin A (ETA) receptor. It is primarily investigated for its potential therapeutic applications in treating various conditions, including cancer and cardiovascular diseases. Zibotentan is characterized by its ability to inhibit the effects of endothelin-1, a potent vasoconstrictor that plays a significant role in regulating blood pressure and vascular tone. By blocking the ETA receptor, Zibotentan may help to reduce tumor growth and improve blood flow in affected tissues. The compound has been studied in clinical trials, particularly in the context of prostate cancer, where endothelin signaling is implicated in tumor progression. Its pharmacological profile includes properties such as oral bioavailability and a favorable safety profile, although specific details regarding its efficacy and side effects are determined through ongoing research. Overall, Zibotentan represents a promising avenue in the development of targeted therapies for diseases associated with endothelin signaling.

Formula: C₁₉H₁₆N₆O₄S

InChI: InChI=1S/C19H16N6O4S/c1-12-10-21-17(19(23-12)28-2)25-30(26,27)15-4-3-9-20-16(15)13-5-7-14(8-6-13)18-24-22-11-29-18/h3-11H,1-2H3,(H,21,25)

InChI key: InChIKey=FJHHZXWJVIEFGJ-UHFFFAOYSA-N

SMILES: S(NC=1C(OC)=NC(C)=CN1)(=O)(=O)C2=C(N=CC=C2)C3=CC=C(C=C3)C4=NN=CO4

Synonyms:

• 3-Pyridinesulfonamide, N-(3-methoxy-5-methyl-2-pyrazinyl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]-
• 3-Pyridinesulfonamide, N-(3-methoxy-5-methylpyrazinyl)-2-(4-(1,3,4-oxadiazol-2-yl)phenyl)-
• N-(3-Methoxy-5-methyl-2-pyrazinyl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]-3-pyridinesulfonamide
• N-(3-Methoxy-5-methylpyrazin-2-yl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]pyridine-3sulfonamide
• Zd 4054
• Zd4054
• Zibotentan

Zibotentan (ZD4054)

CAS: 186497-07-4

Formula: C₁₉H₁₆N₆O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 424.4331

Ref: IN-DA00ABM3

N-(3-Methoxy-5-Methylpyrazin-2-Yl)-2-(4-[1,3,4-Oxadiazol-2-Yl]Phenyl)Pyridine-3-Sulfonamide

CAS: 186497-07-4

N-(3-Methoxy-5-Methylpyrazin-2-Yl)-2-(4-[1,3,4-Oxadiazol-2-Yl]Phenyl)Pyridine-3-Sulfonamide

Purity: 98%

Molecular weight: 424.43g/mol

Ref: 54-OR1023867

Zibotentan

CAS: 186497-07-4

Zibotentan

Purity: ≥95%

Molecular weight: 424.43g/mol

Ref: 54-BUP02100

Zibotentan

CAS: 186497-07-4

Zibotentan (ZD4054) (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.

Formula: C₁₉H₁₆N₆O₄S

Purity: 97.00% - 97.02%

Color and Shape: Solid

Molecular weight: 424.43

Ref: TM-T6258

Zibotentan

Controlled Product

CAS: 186497-07-4

Applications Zibotentan is a specific endothelin-A receptor antagonist that is a potential candidate in the treatment of prostate cancer, bone metastasis and various other types of cancer.
References Carducci, M., Jimeno, A.: Clin. Cancer Res., 12, 6296s (2006); James, N., et al.: Eur Urol., 55, 1112 (2009);

Formula: C₁₉H₁₆N₆O₄S

Color and Shape: Neat

Molecular weight: 424.43

Ref: TR-Z359900