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CAS 186691-13-4

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Tiotropium

Description:
Tiotropium is a long-acting anticholinergic medication primarily used in the management of chronic obstructive pulmonary disease (COPD) and asthma. It functions by inhibiting the action of acetylcholine on muscarinic receptors in the airways, leading to bronchodilation and improved airflow. Tiotropium is characterized by its high affinity for the M3 muscarinic receptor, which is predominantly found in the smooth muscle of the lungs. The substance is typically administered via inhalation, allowing for localized delivery to the respiratory system, which enhances its therapeutic effects while minimizing systemic side effects. Tiotropium is known for its prolonged duration of action, often allowing for once-daily dosing. It is generally well-tolerated, with common side effects including dry mouth and potential cardiovascular effects. The chemical structure of tiotropium includes a quaternary ammonium group, contributing to its pharmacological properties and solubility profile. Overall, tiotropium represents a significant advancement in the treatment of obstructive airway diseases, providing patients with improved respiratory function and quality of life.
Formula:C19H22NO4S2
InChI:InChI=1/C19H22NO4S2/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15/h3-8,11-13,16-17,22H,9-10H2,1-2H3/q+1/t11-,12-,13+,16-,17+
InChI key:InChIKey=LERNTVKEWCAPOY-DZZGSBJMNA-N
SMILES:C(C(O[C@H]1C[C@]2([C@]3([C@@]([C@@](C1)([N+]2(C)C)[H])(O3)[H])[H])[H])=O)(O)(C4=CC=CS4)C5=CC=CS5
Synonyms:
  • (1α,2β,4β,5α,7β)-7-[(2-Hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane
  • 3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane, 7-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-, (1α,2β,4β,5α,7β)-
  • Tiotropium
  • Respimat
  • 3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane, 7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-, (1α,2β,4β,5α,7β)-
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