CAS 186692-46-6
:Roscovitine
Description:
Roscovitine, also known as Seliciclib, is a selective inhibitor of cyclin-dependent kinases (CDKs), particularly CDK2, CDK7, and CDK9, which play crucial roles in cell cycle regulation and transcription. Its chemical formula is C15H16N4O, and it features a purine-like structure that allows it to interfere with the phosphorylation processes essential for cell division and gene expression. Roscovitine has been investigated primarily for its potential therapeutic applications in cancer treatment, as it can induce cell cycle arrest and apoptosis in various cancer cell lines. Additionally, it has shown promise in treating other conditions, such as neurodegenerative diseases, due to its ability to modulate cellular pathways. The compound is typically administered in a pharmaceutical formulation and has undergone various clinical trials to assess its efficacy and safety profile. Its mechanism of action and specificity make it a valuable tool in both research and potential therapeutic contexts, although further studies are necessary to fully understand its effects and optimize its use in clinical settings.
Formula:C19H26N6O
InChI:InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
InChI key:InChIKey=BTIHMVBBUGXLCJ-OAHLLOKOSA-N
SMILES:C(C)(C)N1C=2C(=C(NCC3=CC=CC=C3)N=C(N[C@H](CC)CO)N2)N=C1
Synonyms:- (2R)-2-[[6-(Benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol
- (2R)-2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol
- (2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol
- (R)-Roscovitine
- 1-Butanol, 2-((9-(1-methylethyl)-6-((phenylmethyl)amino)-9H-purin-2-yl)amino)-, (2R)-
- 1-Butanol, 2-((9-(1-methylethyl)-6-((phenylmethyl)amino)-9H-purin-2-yl)amino)-, (R)-
- 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine
- Cyc 202
- Cyc202
- Nsc 701554
- Roscovitin
- Seliciclib
- Unii-0Es1C2Kq94
- See more synonyms
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Found 8 products.
Ref: IN-DA003U50
1gTo inquire1mg51.00€5mg84.00€10mg118.00€25mg180.00€50mg202.00€100mg307.00€250mgTo inquireRoscovitine
CAS:Formula:C19H26N6OPurity:>98.0%(HPLC)(qNMR)Color and Shape:White to Light yellow powder to crystalMolecular weight:354.46Seliciclib
CAS:Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E, also inhibits Cdk7, Cdk5 and Cdc2. Seliciclib has antitumor effect. Cost-effective, quality assurance.Formula:C19H26N6OPurity:97.15% - 99.89%Color and Shape:White To Off-White SolidMolecular weight:354.45Roscovitine
CAS:<p>Applications Roscovitine is a potent and selective inhibitor of cyclin-dependent kinases (CDKs). Roscovitine has been found to produce apoptosis in treated cancerous cells of non-small cell lung cancer (NSCLC) and other cancers. Studies show that Roscovitine displays increased anti-mitotic activity at the G1/S and G2/M phases of the cell cycle. Roscovitine maybe useful in the treatment of non-small cell lung cancer (NSCLC), leukemia, HIV infection, herpes simplex infection, and the mechanisms of chronic inflammation disorders.<br>References De Azevedo, W.F. et al.: Eur. J. Biochem., 43, 518 (1997); Planchais, S. et al.: Plant J., 12, 191 (1997); Mgbonyebi O.P. et al.: Anticancer Res., 18, 751 (1998); MacCallum, D.E. et al.: Cancer Res., 65, 5399 (2005);<br></p>Formula:C19H26N6OColor and Shape:Off White SolidMolecular weight:354.4493(R)-Roscovitine
CAS:<p>M02443 - (R)-Roscovitine</p>Formula:C19H26N6OPurity:>95%Color and Shape:SolidMolecular weight:354.458Roscovitine
CAS:<p>Inhibitor of cyclin-dependend kinases CDC2, CDK2 and CDK5</p>Formula:C19H26N6OPurity:Min. 95%Molecular weight:354.45 g/mol
