CAS 186692-46-6

Roscovitine

Description:

Roscovitine, also known as Seliciclib, is a selective inhibitor of cyclin-dependent kinases (CDKs), particularly CDK2, CDK7, and CDK9, which play crucial roles in cell cycle regulation and transcription. Its chemical formula is C15H16N4O, and it features a purine-like structure that allows it to interfere with the phosphorylation processes essential for cell division and gene expression. Roscovitine has been investigated primarily for its potential therapeutic applications in cancer treatment, as it can induce cell cycle arrest and apoptosis in various cancer cell lines. Additionally, it has shown promise in treating other conditions, such as neurodegenerative diseases, due to its ability to modulate cellular pathways. The compound is typically administered in a pharmaceutical formulation and has undergone various clinical trials to assess its efficacy and safety profile. Its mechanism of action and specificity make it a valuable tool in both research and potential therapeutic contexts, although further studies are necessary to fully understand its effects and optimize its use in clinical settings.

Formula: C₁₉H₂₆N₆O

InChI: InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1

InChI key: InChIKey=BTIHMVBBUGXLCJ-OAHLLOKOSA-N

SMILES: C(C)(C)N1C=2C(=C(NCC3=CC=CC=C3)N=C(N[C@H](CC)CO)N2)N=C1

Synonyms:

• (2R)-2-[[6-(Benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol
• (2R)-2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol
• (2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol
• (R)-Roscovitine
• 1-Butanol, 2-((9-(1-methylethyl)-6-((phenylmethyl)amino)-9H-purin-2-yl)amino)-, (2R)-
• 1-Butanol, 2-((9-(1-methylethyl)-6-((phenylmethyl)amino)-9H-purin-2-yl)amino)-, (R)-
• 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine
• Cyc 202
• Cyc202
• Nsc 701554
• Roscovitin
• Seliciclib
• Unii-0Es1C2Kq94

Roscovitine

CAS: 186692-46-6

Formula: C₁₉H₂₆N₆O

Purity: 98%

Color and Shape: Solid

Molecular weight: 354.4493

Ref: IN-DA003U50

Seliciclib

CAS: 186692-46-6

Seliciclib

Purity: ≥95%

Molecular weight: 354.45g/mol

Ref: 54-BUP13499

Roscovitine

CAS: 186692-46-6

Formula: C₁₉H₂₆N₆O

Purity: >98.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 354.46

Ref: 3B-R0207

Roscovitine

CAS: 186692-46-6

Formula: C₁₉H₂₆N₆O

Molecular weight: 354.45

Ref: 7W-GP3424

Seliciclib

CAS: 186692-46-6

Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E, also inhibits Cdk7, Cdk5 and Cdc2. Seliciclib has antitumor effect. Cost-effective, quality assurance.

Formula: C₁₉H₂₆N₆O

Purity: 97.15% - 99.89%

Color and Shape: White To Off-White Solid

Molecular weight: 354.45

Ref: TM-T2095

Roscovitine

CAS: 186692-46-6

Applications Roscovitine is a potent and selective inhibitor of cyclin-dependent kinases (CDKs). Roscovitine has been found to produce apoptosis in treated cancerous cells of non-small cell lung cancer (NSCLC) and other cancers. Studies show that Roscovitine displays increased anti-mitotic activity at the G1/S and G2/M phases of the cell cycle. Roscovitine maybe useful in the treatment of non-small cell lung cancer (NSCLC), leukemia, HIV infection, herpes simplex infection, and the mechanisms of chronic inflammation disorders.
References De Azevedo, W.F. et al.: Eur. J. Biochem., 43, 518 (1997); Planchais, S. et al.: Plant J., 12, 191 (1997); Mgbonyebi O.P. et al.: Anticancer Res., 18, 751 (1998); MacCallum, D.E. et al.: Cancer Res., 65, 5399 (2005);

Formula: C₁₉H₂₆N₆O

Color and Shape: Off White Solid

Molecular weight: 354.4493

Ref: TR-R684000

(R)-Roscovitine

CAS: 186692-46-6

M02443 - (R)-Roscovitine

Formula: C₁₉H₂₆N₆O

Purity: >95%

Color and Shape: Solid

Molecular weight: 354.458

Ref: 10-M02443

Roscovitine

CAS: 186692-46-6

Inhibitor of cyclin-dependend kinases CDC2, CDK2 and CDK5

Formula: C₁₉H₂₆N₆O

Purity: Min. 95%

Molecular weight: 354.45 g/mol

Ref: 3D-FR146851