CAS 1868135-06-1

Sofosbuvir-d6

CAS: 1868135-06-1

Formula: C₂₂H₂₃D₆FN₃O₉P

Molecular weight: 535.49

Ref: 4Z-S-055085

PSI-7977-d6

Controlled Product

CAS: 1868135-06-1

Applications Isotope labelled PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
References Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010);

Formula: C₂₂D₆H₂₃FN₃O₉P

Color and Shape: Neat

Molecular weight: 535.49

Ref: TR-P839644

Sofosbuvir d6

CAS: 1868135-06-1

Sofosbuvir d6 is a deuterated antiviral drug used for the treatment of Hepatitis C virus (HCV) infection, which is synthesized chemically. This modification involves the replacement of hydrogen atoms with deuterium, a stable isotope of hydrogen, resulting in enhanced pharmacokinetic properties. By incorporating deuterium, the metabolic stability of the compound is improved due to the kinetic isotope effect, which slows down the metabolic degradation of the compound.

Formula: C₂₂H₂₉FN₃O₉P

Purity: Min. 95%

Molecular weight: 535.5 g/mol

Ref: 3D-TZC13506