CAS 18684-24-7

Prolylhydroxyproline

Description:

Prolylhydroxyproline, with the CAS number 18684-24-7, is a naturally occurring amino acid derivative that is a modified form of proline. It is characterized by the presence of a hydroxyl group attached to the proline structure, which enhances its solubility and reactivity. This compound is often found in collagen and is significant in the context of protein synthesis and stability, particularly in connective tissues. Prolylhydroxyproline plays a role in the stabilization of collagen triple helices, contributing to the structural integrity of various tissues. It is also studied for its potential therapeutic applications, including its effects on wound healing and tissue repair. In terms of physical properties, prolylhydroxyproline is typically a white crystalline solid, soluble in water, and exhibits a specific melting point range. Its biochemical properties make it of interest in both nutritional and pharmaceutical research, particularly in the development of supplements aimed at improving skin health and joint function.

Formula: C₁₀H₁₆N₂O₄

InChI: InChI=1S/C10H16N2O4/c13-6-4-8(10(15)16)12(5-6)9(14)7-2-1-3-11-7/h6-8,11,13H,1-5H2,(H,15,16)/t6-,7+,8+/m1/s1

InChI key: InChIKey=ONPXCLZMBSJLSP-CSMHCCOUSA-N

SMILES: C(=O)(N1[C@H](C(O)=O)C[C@@H](O)C1)[C@@H]2CCCN2

Synonyms:

• (2E)-non-2-enal
• <span class="text-smallcaps">L</smallcap>-Proline, 4-hydroxy-1-<smallcap>L</span>-prolyl-, trans-
• <span class="text-smallcaps">L</smallcap>-Proline, <smallcap>L</span>-prolyl-4-hydroxy-, (4R)-
• <span class="text-smallcaps">L</smallcap>-Prolyl-<smallcap>L</span>-hydroxyproline
• G 3025
• H-Pro-Hyp-OH
• Proline, 4-hydroxy-1-<span class="text-smallcaps">L</smallcap>-prolyl-, <smallcap>L</span>-
• Proline, 4-hydroxy-1-<span class="text-smallcaps">L</span>-prolyl-
• Prolylhydroxyproline
• L-Proline, 4-hydroxy-1-L-prolyl-, trans-
• L-Proline, L-prolyl-4-hydroxy-, (4R)-
• Proline, 4-hydroxy-1-L-prolyl-, L-

H-Pro-Hyp-OH

CAS: 18684-24-7

According to Shigemura et al. Pro-Hyp, a food-derived collagen peptide in human blood, stimulates the growth of fibroblasts from mouse skin. Nakatani et al. observed a chondroprotective effect of the dipeptide in mouse articular cartilage. Inoue et al. showed in a clinical study that ingestion of the dipeptides Pro-Hyp and Hyp-Gly could improve facial skin moisture and elasticity and reduce facial ageing.

Formula: C₁₀H₁₆N₂O₄

Purity: > 98%

Color and Shape: White

Molecular weight: 228.25

Ref: 01-4001630

H-Pro-Hyp-OH

CAS: 18684-24-7

Formula: C₁₀H₁₆N₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 228.2450

Ref: IN-DA007S66

H-Pro-Hyp-OH

CAS: 18684-24-7

H-Pro-Hyp-OH

Purity: 98%

Molecular weight: 228.25g/mol

Ref: 54-OR1005614

Pro-Hyp-OH

Controlled Product

CAS: 18684-24-7

Formula: C₁₀H₁₆N₂O₄

Color and Shape: Neat

Molecular weight: 228.25

Ref: TR-P839375

Pro-Hyp-OH

CAS: 18684-24-7

Pro-Hyp-OH is a model system of the human collagen prolyl hydroxylase. It is a glycoprotein that converts the inactive pro-collagen to the active collagen. Pro-Hyp-OH has been shown to have anti-inflammatory effects and may be used as a potential treatment for skin disorders. This product has also been found to increase the rate of transport of glycopeptides across 3T3-L1 preadipocytes, which may be due to its ability to bind to collagen. The structural analysis of Pro-Hyp-OH has revealed that it is composed of two domains, one with an alpha helical structure and another in beta sheet form. This product is also used in the diagnosis of collagen diseases such as osteogenesis imperfecta, Ehlers Danlos syndrome type IV, and dermatosparaxis.

Formula: C₁₀H₁₆N₂O₄

Purity: (%) Min. 90%

Color and Shape: White Powder

Molecular weight: 228.25 g/mol

Ref: 3D-FP49344

(2S,4R)-1-(L-prolyl)-4-hydroxypyrrolidine-2-carboxylic acid

CAS: 18684-24-7

Purity: 95%

Molecular weight: 228.2480011

Ref: 10-F771517