CAS 186953-56-0

Pafuramidine

Description:

Pafuramidine, also known by its developmental code name DB289, is a synthetic compound primarily investigated for its potential as an antiprotozoal agent, particularly against infections caused by Trypanosoma brucei, the causative agent of sleeping sickness. It belongs to the class of compounds known as diamidines, which are characterized by their ability to intercalate into DNA, thereby disrupting cellular processes. Pafuramidine exhibits a favorable pharmacokinetic profile, including good oral bioavailability and tissue distribution. Its mechanism of action involves the inhibition of nucleic acid synthesis in the target organisms. The compound has shown promise in preclinical studies and clinical trials, demonstrating efficacy against various protozoan infections. Additionally, it has been noted for its relatively low toxicity in comparison to other treatments. However, as with many investigational drugs, further studies are necessary to fully understand its safety, efficacy, and potential side effects in diverse populations. Overall, pafuramidine represents a significant advancement in the search for effective treatments for neglected tropical diseases.

Formula: C₂₀H₂₀N₄O₃

InChI: InChI=1S/C20H20N4O3/c1-25-23-19(21)15-7-3-13(4-8-15)17-11-12-18(27-17)14-5-9-16(10-6-14)20(22)24-26-2/h3-12H,1-2H3,(H2,21,23)(H2,22,24)

InChI key: InChIKey=UKOQVLAXCBRRGH-UHFFFAOYSA-N

SMILES: C(NOC)(=N)C1=CC=C(C=2OC(=CC2)C3=CC=C(C(NOC)=N)C=C3)C=C1

Synonyms:

• 4,4′-(2,5-Furandiyl)bis[N-methoxybenzenecarboximidamide]
• Benzenecarboximidamide, 4,4′-(2,5-furandiyl)bis[N-methoxy-
• Pafuramidine
• 2,5-Bis(4-amidinophenyl)furan-bis-O-methylamidoxime

Pafuramidine

CAS: 186953-56-0

Formula: C₂₀H₂₀N₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 364.3978

Ref: IN-DA00ABL7

Pafuramidine

CAS: 186953-56-0

Pafuramidine

Purity: ≥98%

Molecular weight: 364.4g/mol

Ref: 54-BUP01868

Pafuramidine

CAS: 186953-56-0

Pafuramidine (DB289) is an experimental prodrug of the metabolite DB75, an antiparasitic compound with antimalarial activity.

Formula: C₂₀H₂₀N₄O₃

Purity: 98.34%

Color and Shape: Solid

Molecular weight: 364.4

Ref: TM-T16428

Pafuramidine

Controlled Product

CAS: 186953-56-0

Applications Pafuramidine is a prodrug of Furamidine (F863600, 2HCl); a diphenylfuran compound belonging to an important class of antimicrobial and antiparasitic agents. Furamidine and its analogues also display antitumor activities and showed antiproliferative activities against various tumor cell lines.
References Lansiaux, A. et al.: Cancer Res., 62, 7219 (2002); Steck E.A. et al.: Exp. Parasitol., 52, 404 (1981); Balzarini, J. et al.: Incest. New Drugs, 1, 103 (1983); Thuita, J.K., et al.: Acta Trop., 108, 6 (2008); Lanteri, C.A., et al.: Mol. Pharmacol., 70, 1585 (2006)

Formula: C₂₀H₂₀N₄O₃

Color and Shape: Neat

Molecular weight: 364.4

Ref: TR-P133875

Pafuramidine

CAS: 186953-56-0

Pafuramidine is an antiprotozoal prodrug with action on protozoal DNA synthesis inhibition and is used for treating African sleeping sickness and Pneumocystis pneumonia.

Formula: C₂₀H₂₀N₄O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 364.4 g/mol

Ref: 3D-FP76412