CAS 187034-31-7

N1-((S)-1-(((S)-1-((2-Aminoethyl)amino)-1-oxopropan-2-yl)amino)-3,3-dimethyl-1-oxobutan-2-yl)-N4-hydroxy-2-isobutylsuccinamide

CAS: 187034-31-7

N1-((S)-1-(((S)-1-((2-Aminoethyl)amino)-1-oxopropan-2-yl)amino)-3,3-dimethyl-1-oxobutan-2-yl)-N4-hydroxy-2-isobutylsuccinamide

Purity: 99%

Molecular weight: 415.54g/mol

Ref: 54-OR1066080

TNF Protease Inhibitor 2

CAS: 187034-31-7

TAPI-2 is a broad-spectrum inhibitor of MMP (IC50: 20 μM), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM).

Formula: C₁₉H₃₇N₅O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 415.53

Ref: TM-TQ0129

TAPI-2

CAS: 187034-31-7

TAPI-2 is an inhibitor of ADAM-17 (also called TACE) and matrix metalloproteinases (MMPs). It acts as a broad-spectrum inhibitor of these enzymes. TAPI-2 prevents the shedding of tumor necrosis factor-alpha (TNF-α) from cell membranes and can sensitize cancer stem cells to the effects of chemotherapy such as 5-fluorouracil (5-FU) in vitro. It also blocks the phorbol ester-induced shedding of other cell surface proteins like TGF-α and β-amyloid precursor protein.

Formula: C₁₉H₃₇N₅O₅

Purity: Min. 95%

Molecular weight: 415.53 g/mol

Ref: 3D-MHA03431