CAS 187224-29-9

ARA-S

Description:

ARA-S, with the CAS number 187224-29-9, is a synthetic compound that belongs to the class of arachidonic acid derivatives. It is primarily recognized for its role as a selective inhibitor of certain enzymes involved in the metabolism of arachidonic acid, particularly in the context of inflammatory processes. ARA-S exhibits anti-inflammatory properties, making it of interest in pharmacological research, particularly for conditions characterized by excessive inflammation. The compound's mechanism of action typically involves modulation of signaling pathways related to prostaglandin synthesis, which are crucial in mediating inflammatory responses. Additionally, ARA-S may have implications in various therapeutic areas, including pain management and the treatment of inflammatory diseases. Its chemical structure and properties facilitate interactions with biological targets, contributing to its potential efficacy. As with many synthetic compounds, understanding its pharmacokinetics, toxicity, and long-term effects is essential for evaluating its safety and therapeutic potential in clinical applications.

Formula: C₂₃H₃₇NO₄

Synonyms:

• N-[1-Oxo-(5Z,8Z,11Z,14Z-Eicosatetraenyl)]-L-Serine
• N-Arachidonoyl L-Serine

N-[1-oxo-5(Z),8(Z),11(Z),14(Z)-eicosatetraenyl]-L-serine

CAS: 187224-29-9

Formula: C23H37NO4

Purity: >98%

Color and Shape: In solution, Ethanol

Molecular weight: 391.55

Ref: 48-18-2092

N-Arachidonoyl-L-Serine

CAS: 187224-29-9

N-Arachidonoyl-L-serine (ARA-S), a recently isolated endocannabinoid with a distinct activity profile that diverges from typical endocannabinoids, does not interact with central cannabinoid (CB1), peripheral cannabinoid (CB2) receptors, or vanilloid receptor 1 (VR1). Unlike other compounds, ARA-S (5 mg/kg) counteracts the lowering of blood pressure induced by a 10 mg/kg intravenous bolus of abnormal cannabidiol (Abn-CBD) in anesthetized rat models. Additionally, akin to Abn-CBD, ARA-S induces relaxation in isolated rat mesenteric arteries and abdominal aorta and promotes phosphorylation of Akt and mitogen-activated protein kinase (MAPK) in human umbilical vein endothelial cells (HUVEC). The mechanisms through which ARA-S and Abn-CBD exert their effects on vascular systems show variations and merit deeper investigation.

Formula: C₂₃H₃₇NO₄

Color and Shape: Solid

Molecular weight: 391.5

Ref: TM-T84551