CAS 187235-37-6: PA 824

Description: PA-824, with the CAS number 187235-37-6, is a synthetic compound primarily studied for its potential use in treating tuberculosis, particularly drug-resistant strains. It belongs to the class of nitroimidazoles and exhibits bactericidal activity against Mycobacterium tuberculosis. PA-824 functions through a unique mechanism of action, where it is activated under anaerobic conditions, leading to the generation of reactive nitrogen species that disrupt bacterial cellular processes. This compound is characterized by its ability to penetrate the mycobacterial cell wall effectively, making it a promising candidate in tuberculosis therapy. Additionally, PA-824 has shown favorable pharmacokinetic properties, including oral bioavailability and a prolonged half-life, which support its potential for once-daily dosing regimens. Research continues to evaluate its efficacy and safety in clinical settings, particularly in combination therapies aimed at enhancing treatment outcomes for patients with multidrug-resistant tuberculosis. Overall, PA-824 represents a significant advancement in the search for effective anti-tuberculosis agents.

Formula: C₁₄H₁₂F₃N₃O₅

InChI: InChI=1S/C14H12F3N3O5/c15-14(16,17)25-10-3-1-9(2-4-10)7-23-11-5-19-6-12(20(21)22)18-13(19)24-8-11/h1-4,6,11H,5,7-8H2/t11-/m0/s1

InChI key: InChIKey=ZLHZLMOSPGACSZ-NSHDSACASA-N

SMILES: O=N(=O)C=1N=C2OCC(OCC3=CC=C(OC(F)(F)F)C=C3)CN2C1

Synonyms:

• (6S)-2-Nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
• (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
• (6S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine
• (S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
• (S)-6-[[4-(Trifluoromethoxy)benzyl]oxy]-6,7-dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazine
• (S)-Pa 824
• 5H-Imidazo[2,1-b][1,3]oxazine, 6,7-dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-, (6S)-
• 5H-Imidazo[2,1-b][1,3]oxazine, 6,7-dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-, (S)-
• Pa-824
• Pretomanid

PA-824

CAS: 187235-37-6

• Formula: C₁₄H₁₂F₃N₃O₅
• Purity: >98.0%(HPLC)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 359.26

PA-824

CAS: 187235-37-6

• Formula: C₁₄H₁₂F₃N₃O₅
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 359.2574

(S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

CAS: 187235-37-6

• Formula: C₁₄H₁₂F₃N₃O₅
• Purity: 98%
• Color and Shape: pale yellow solid
• Molecular weight: 359.26g/mol

Pretomanid (PA-824)

CAS: 187235-37-6

• Formula: C₁₄H₁₂F₃N₃O₅
• Color and Shape: White To Off-White Solid
• Molecular weight: 359.26

Pretomanid

CAS: 187235-37-6

Pretomanid ((S)-PA 824) , a nitroimidazole, is used as an anti-tuberculosis drug for tuberculosis with …

• Formula: C₁₄H₁₂F₃N₃O₅
• Purity: 98.75% - 99.56%
• Color and Shape: Solid
• Molecular weight: 359.26

(S)-PA 824 (Pretomanid)

CAS: 187235-37-6

Applications A novel anti-tuberculosis drug. References Diacon, A.H. et al.: Antimicrob. Anents Chemother., 54, 3402 …

• Formula: C₁₄H₁₂F₃N₃O₅
• Color and Shape: Neat
• Molecular weight: 359.26

(S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

CAS: 187235-37-6

• Purity: 95.0%
• Color and Shape: Liquid, No data available.
• Molecular weight: 359.260986328125

(S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine

CAS: 187235-37-6

Please enquire for more information about (S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine including the price, delivery time and more detailed …

• Formula: C₁₄H₁₂F₃N₃O₅
• Purity: Min. 98 Area-%
• Color and Shape: Off-White Slightly Yellow Powder
• Molecular weight: 359.26 g/mol