CAS 187389-52-2

N-[(benzyloxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide

Description:

N-[(benzyloxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide, with CAS number 187389-52-2, is a synthetic compound that belongs to the class of amino acid derivatives. This substance features a complex structure characterized by the presence of a benzyloxycarbonyl group, which is commonly used to protect amino groups in peptide synthesis. The compound contains L-valine and L-alanine residues, indicating its relevance in biochemistry and potential applications in peptide synthesis or drug development. The presence of a fluorinated moiety and a methoxy-oxoethyl group suggests that it may exhibit unique biological activities or properties, possibly enhancing its pharmacological profile. As with many synthetic peptides, its solubility, stability, and reactivity can be influenced by the specific functional groups present. Overall, this compound may be of interest in medicinal chemistry, particularly in the design of novel therapeutics or as a research tool in biochemical studies.

Formula: C₂₂H₃₀FN₃O₇

InChI: InChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1

InChI key: InChIKey=MIFGOLAMNLSLGH-QOKNQOGYSA-N

SMILES: [C@H](NC([C@@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)[C@H](C)C)=O)C)=O)(CC(OC)=O)C(CF)=O

Synonyms:

• 13: PN: WO2005039629 PAGE: 18 claimed protein
• 3: PN: WO2011028611 SEQID: 3 unclaimed protein
• <span class="text-smallcaps">L</smallcap>-Alaninamide, N-[(phenylmethoxy)carbonyl]-<smallcap>L</span>-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-
• L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-
• N-[(Benzyloxy)carbonyl]-L-valyl-N-[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]-L-alaninamide
• N-[(Phenylmethoxy)Carbonyl]-L-Valyl-N-[(1S)-3-Fluoro-1-(2-Methoxy-2-Oxoethyl)-2-Oxopropyl]-L-Alaninamide
• N-[(Phenylmethoxy)carbonyl]-<span class="text-smallcaps">L</smallcap>-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-<smallcap>L</span>-alaninamide
• Z-VAD(OMe)-FMK
• Z-Val-Ala-Asp(OMe)-FMK
• z-VAD-FMK
• 3: PN: WO0158526 SEQID: 3 claimed sequence

methyl 5-fluoro-3-[2-[[3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoylamino]-4-oxopentanoate

CAS: 187389-52-2

Formula: C₂₂H₃₀FN₃O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 467.4879

Ref: IN-DA01DOTL

Z-VAD(OMe)-FMK

CAS: 187389-52-2

Z-VAD(OMe)-FMK

Purity: ≥95%

Molecular weight: 467.49g/mol

Ref: 54-BUP08852

Z-VAD(OMe)-FMK

CAS: 187389-52-2

Z-VAD(OMe)-FMK

Purity: 98%

Molecular weight: 467.49g/mol

Ref: 54-BISN0146

Z-VAD(OMe)-FMK

CAS: 187389-52-2

View and buy Z-VAD(OMe)-FMK from TargetMol.Z-VAD(OMe)-FMK is a cell-permeable and irreversible pan-caspase inhibitor.Cited in 10 publications.

Formula: C₂₂H₃₀FN₃O₇

Purity: 95.92% - 99.71%

Color and Shape: Solid

Molecular weight: 467.49

Ref: TM-T6013

Z-VAD-FMK, cell permeable

CAS: 187389-52-2

Formula: C₂₂H₃₀FN₃O₇

Purity: ≥ 95.0%

Color and Shape: White to off-white solid

Molecular weight: 467.5

Ref: 7W-GL1523

Z-VAD-FMK

Controlled Product

CAS: 187389-52-2

Applications Z-VAD-FMK is a caspase inhibitor that inhibits apoptosis and caspase processing in Jurkat T cells treated with low concentrations of z-FA-CMK.
References Liow, K.Y., Chow, S.C.: Toxicol. App. Pharmacol., 272, 559 (2013)

Formula: C₂₂H₃₀FN₃O₇

Color and Shape: Neat

Molecular weight: 467.49

Ref: TR-Z359870

Methyl (5S,8S,11S)-11-(2-fluoroacetyl)-5-isopropyl-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oate

CAS: 187389-52-2

Purity: 98%

Molecular weight: 467.493988

Ref: 10-F869530

Caspase-1 Inhibitor Z-Val-Ala-DL-Asp-fluoromethylketone

CAS: 187389-52-2

M01478 - Caspase-1 Inhibitor Z-Val-Ala-DL-Asp-fluoromethylketone

Formula: C₂₂H₃₀FN₃O₇

Purity: 98+%

Molecular weight: 467.494

Ref: 10-M01478

Z-Val-Ala-Asp(OMe)-CH2F [Z-VAD-FMK]

CAS: 187389-52-2

Z-Val-Ala-Asp(OMe)-CH2F is a peptide that belongs to the ion channel inhibitor family. It has been shown to inhibit potassium channels and voltage-gated sodium channels, which are important for regulating the flow of ions in cells. Z-Val-Ala-Asp(OMe)-CH2F has also been shown to bind to the receptor for tumor necrosis factor α and downregulate its activity. Z-Val-Ala-Asp(OMe)-CH2F is a useful tool for studying protein interactions and cellular processes such as apoptosis, inflammation, and cell growth.

Formula: C₂₂H₃₀N₃O₇F

Purity: Min. 95%

Molecular weight: 467.49 g/mol

Ref: 3D-ICA-3188-V