Verubecestat tosylate is a chemical compound primarily studied for its potential use in treating Alzheimer's disease. It acts as a selective inhibitor of the enzyme beta-secretase (BACE1), which plays a crucial role in the production of amyloid-beta peptides, implicated in the pathogenesis of Alzheimer's. The tosylate salt form enhances its solubility and stability, making it more suitable for pharmaceutical applications. In terms of its chemical structure, Verubecestat features a complex arrangement that includes a bicyclic core, contributing to its biological activity. The compound has undergone various clinical trials to evaluate its efficacy and safety profile, although results have shown mixed outcomes. Its pharmacokinetics indicate that it is metabolized primarily in the liver, with a focus on understanding its interactions with other medications. Overall, Verubecestat tosylate represents a significant area of research in neurodegenerative disease treatment, reflecting ongoing efforts to develop effective therapies for Alzheimer's disease.

Verubecestat tosylate

1875153-95-9: Verubecestat tosylate is a chemical compound primarily studied for its potential use in treating Alzheimer's disease. It acts as a selective inhibitor of the enzyme beta-secretase (BACE1), which plays a crucial role in the production of amyloid-beta peptides, implicated in the pathogenesis of Alzheimer's. The tosylate salt form enhances its solubility and stability, making it more suitable for pharmaceutical applications. In terms of its chemical structure, Verubecestat features a complex arrangement that includes a bicyclic core, contributing to its biological activity. The compound has undergone various clinical trials to evaluate its efficacy and safety profile, although results have shown mixed outcomes. Its pharmacokinetics indicate that it is metabolized primarily in the liver, with a focus on understanding its interactions with other medications. Overall, Verubecestat tosylate represents a significant area of research in neurodegenerative disease treatment, reflecting ongoing efforts to develop effective therapies for Alzheimer's disease.

Verubecestat (MK-8931/SCH 900931) is a potent BACE1 inhibitor, promising for Alzheimer’s, reducing Aβ in CSF by up to 92%.

CAS 1875153-95-9

Verubecestat tosylate

Verubecestat tosylate

Ref: TM-T70104